| Comparison of the antioxidant activity amongst Gingko biloba extract and its main components. | |
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MedLine Citation:
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PMID: 19771849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the antioxidant activity amongst the extract of Ginkgo biloba (EGb) and its main components, flavonoids and terpenoids. METHODS: The induction of EGb, flavonoids and terpenoids on a typical antioxidant enzyme, glutamate cysteine ligase catalytic subunit (GCLC), in cell lines was detected by Western-blot. The effects of EGb, flavonoids and terpenoids on superoxide anion radical (O2*(-)), hydroxyl radical (OH*), rat erythrocyte hemolysis and lipid peroxidation of rat liver homogenate were determined by respective activity methods. RESULTS: EGb and flavonoids but not terpenoids were demonstrated significantly to induce the antioxidant enzyme (GCLC), directly scavenge O2*(-), OH* and inhibit rat erythrocyte hemolysis and lipid peroxidation of rat liver homogenate. Compared these antioxidant activities between EGb and flavonoids, the activities of flavonoids were weaker than those of EGb, which contains similar dose of flavonoids. CONCLUSION: EGb has stronger antioxidant activities than flavonoids, but terpenoids did not show antioxidant activity in this research. |
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Authors:
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Xiao-Ping Liu; Jia-Jie Luan; Christopher E P Goldring |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials Volume: 32 ISSN: 1001-4454 ISO Abbreviation: Zhong Yao Cai Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-09-23 Completed Date: 2009-12-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9426370 Medline TA: Zhong Yao Cai Country: China |
Other Details:
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Languages: eng Pagination: 736-40 Citation Subset: IM |
Affiliation:
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Institute of Pharmacy and Therapeutics,Wannan Medical College, Wuhu 241001, China. liuxiaoping@wnmc.edu.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / isolation & purification, pharmacology* Blotting, Western Cells, Cultured Flavonoids / pharmacology Free Radical Scavengers / pharmacology Free Radicals / metabolism* Ginkgo biloba / chemistry* Glutamate-Cysteine Ligase / metabolism Hemolysis / drug effects Lipid Peroxidation / drug effects Liver / drug effects*, metabolism Plant Extracts / chemistry, isolation & purification, pharmacology* Plant Leaves / chemistry Rats Terpenes / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Flavonoids; 0/Free Radical Scavengers; 0/Free Radicals; 0/Plant Extracts; 0/Terpenes; EC 6.3.2.2/Glutamate-Cysteine Ligase |
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