Document Detail


Comparison of antihypertensive efficacy and perinatal safety of labetalol and methyldopa in the treatment of hypertension in pregnancy: a randomized controlled trial.
MedLine Citation:
PMID:  3056503     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Labetalol was compared with methyldopa in a randomized controlled trial involving 176 pregnant women with mild to moderate hypertension. Diastolic blood pressure below 86 mmHg was obtained in a similar proportion of women given labetalol or methyldopa. Intrauterine death occurred in four women treated with methyldopa, and the one neonatal death on day 1 occurred in the labetalol group. The average birthweight and the proportion of preterm or small-for-gestational-age babies were similar in both groups. Heart rate, blood pressure, blood glucose, respiratory rate, and Silverman score of the babies did not differ between the two treatment groups, whether the comparison was made for all the infants, or only for those that were preterm or small-for-gestational-age. These data indicate that maternal beta-blockade with labetalol is as safe as methyldopa for the fetus and the newborn.
Authors:
P F Plouin; G Breart; F Maillard; E Papiernik; J P Relier
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  95     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-12-30     Completed Date:  1988-12-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  868-76     Citation Subset:  AIM; IM    
Affiliation:
Service d'Hypertension, Hôpital Broussais, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Clinical Trials as Topic
Female
Fetal Death
Fetus / drug effects
Hemodynamics / drug effects
Humans
Hypertension / drug therapy*
Infant, Newborn
Labetalol / therapeutic use*
Methyldopa / therapeutic use*
Pregnancy
Pregnancy Complications, Cardiovascular / drug therapy*
Prenatal Care
Random Allocation
Respiration / drug effects
Chemical
Reg. No./Substance:
36894-69-6/Labetalol; 555-30-6/Methyldopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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