Document Detail

Comparison of antihypertensive efficacy of carvedilol and nebivolol in mild-to-moderate primary hypertension: a randomized trial.
MedLine Citation:
PMID:  21543293     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of the present study is to compare the antihypertensive effects of carvedilol and nebivolol in mild-to-moderate hypertensive patients.
METHODS: It is a prospective; placebo-controlled, cross-over, double-blind, randomized, single-center clinical trial. Patients (n=20) who were first diagnosed with mild to moderate systemic hypertension according to mean ambulatory blood pressure measurements > 130/85 mmHg and no previous antihypertensive therapy were prospectively enrolled into the study. After 10 days of placebo run-in period, they were randomized within the same group as cross-over design to one month carvedilol 25 mg and one month nebivolol 5 mg regimen given once daily in the morning. The primary outcome variables were systolic and diastolic blood pressures determined by 24-hour ambulatory blood pressure measurements. Mutlivariate analysis of variance for repeated measurements with 3x2 factorial design was used for statistical analysis of results.
RESULTS: The study group consisted of 6 women and 14 men whose mean age was 42.9±12.8 years (range 19-63 years). Mean heart rate was significantly decreased after commencing both carvedilol (70.2±5.2 bpm) and nebivolol (64.9±3.9 bpm) treatments compared to placebo (78.8±5.2 bpm) (p<0.05). Both carvedilol (133.8±9/86.6±8.6 mmHg) and nebivolol (134±8.7/85.6±7.4 mmHg) significantly decreased mean systolic and diastolic blood pressures compared to placebo (143.9±8.9/94.4±9.2 mmHg), respectively (p<0.05). However, there was no significant difference in decreasing either systolic or diastolic blood pressure between nebivolol and carvedilol therapies (p>0.05). No side effects were recorded during both carvedilol and nebivolol treatments.
CONCLUSION: Although both carvedilol and nebivolol effectively decreased blood pressure compared to placebo, they showed similar efficacy for lowering blood pressure.
Okan Erdoğan; Bülent Ertem; Armağan Altun
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2011-05-05
Journal Detail:
Title:  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology     Volume:  11     ISSN:  1308-0032     ISO Abbreviation:  Anadolu Kardiyol Derg     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-30     Completed Date:  2011-12-22     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  101095069     Medline TA:  Anadolu Kardiyol Derg     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  310-3     Citation Subset:  IM    
Department of Cardiology, Faculty of Medicine, Marmara University, İstanbul, Turkey.
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MeSH Terms
Antihypertensive Agents / administration & dosage*
Benzopyrans / administration & dosage*
Blood Pressure
Carbazoles / administration & dosage*
Cross-Over Studies
Double-Blind Method
Ethanolamines / administration & dosage*
Hypertension / drug therapy*,  pathology
Middle Aged
Propanolamines / administration & dosage*
Prospective Studies
Severity of Illness Index
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Antihypertensive Agents; 0/Benzopyrans; 0/Carbazoles; 0/Ethanolamines; 0/Propanolamines; 030Y90569U/nebivolol; 0K47UL67F2/carvedilol

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