Document Detail


Comparison of anticonvulsant effect of ethanol against NMDA-, kainic acid- and picrotoxin-induced convulsions in rats.
MedLine Citation:
PMID:  2406529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The anticonvulsant effect of ethanol against N-methyl-D-aspartic acid-(NMDA), kainic acid-, and picrotoxin-induced convulsions was studied in rats. Ethanol (2 g/kg, ip) offered protection against these agents, and it was most effective against picrotoxin and least effective against kainic acid. MK801, NMDA receptor antagonist, also provided protection against these agents. However, it was most effective against NMDA and least effective against kainic acid. Ineffective doses of MK801 (0.1 mg/kg, ip) and ethanol (0.5 g/kg, ip), when administered concurrently, had a facilitatory anticonvulsant effect, thereby providing protection against mortality following severe convulsions induced by NMDA or picrotoxin, but not against kainic acid. The protective effect of ethanol against NMDA- and kainic acid-induced neurotoxicity, in contrast to picrotoxin-induced toxicity, was not reversed by imidazodiazepine, Ro 15-4513, an ethanol antagonist. Furthermore, Ro 15-4513 did not produce any proconvulsant effect with NMDA or kainic acid. These findings suggested that the anticonvulsant actions of ethanol may be attributed to its ability to antagonize NMDA-mediated excitatory responses and facilitate the GABAergic transmission.
Authors:
S K Kulkarni; A K Mehta; M K Ticku
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Life sciences     Volume:  46     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1990  
Date Detail:
Created Date:  1990-03-23     Completed Date:  1990-03-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  481-7     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284-7764.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticonvulsants / pharmacology,  therapeutic use
Aspartic Acid / analogs & derivatives*,  antagonists & inhibitors
Dibenzocycloheptenes / pharmacology,  therapeutic use
Dizocilpine Maleate
Drug Synergism
Ethanol / pharmacology,  therapeutic use*
Kainic Acid / antagonists & inhibitors*
Male
N-Methylaspartate
Picrotoxin / antagonists & inhibitors*
Rats
Rats, Inbred Strains
Seizures / prevention & control*
Grant Support
ID/Acronym/Agency:
AA-04090/AA/NIAAA NIH HHS; NS-15339/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Dibenzocycloheptenes; 124-87-8/Picrotoxin; 487-79-6/Kainic Acid; 56-84-8/Aspartic Acid; 6384-92-5/N-Methylaspartate; 64-17-5/Ethanol; 77086-22-7/Dizocilpine Maleate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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