| Comparison of antibiotic-only and antibiotic-steroid combination treatment in corneal ulcer patients: double-blinded randomized clinical trial. | |
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MedLine Citation:
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PMID: 21283156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the benefit of early addition of corticosteroids to antibiotics in the treatment of corneal ulcers. DESIGN: Randomized clinical trial. PARTICIPANTS: Thirty eyes of 30 patients, over the age of 12 years, with bacterial corneal ulcer confirmed by culture. METHODS: Patients were randomized before enrollment; 15 were treated with gatifloxacin (Zymar) and a masked placebo and the other 15 were treated with gatifloxacin and masked dexamethasone 0.1% (Maxidex). Primary outcome was residual ulcer size at 10 weeks based on digital photographs. Secondary outcomes included residual ulcer area by clinician estimate, visual acuity, VF-14 score, and time to healing. RESULTS: All subjects (n = 30) demonstrated a reduction in ulcer size over the study period. There was no significant difference between the 2 groups in terms of the primary outcome. There was a significant difference between the 2 groups in 1 of the secondary outcomes. The mean residual ulcer size compared with the baseline by clinician estimate (slit-lamp) was -0.789 mm2 for the antibiotic-only group and -4.206 mm2 for the antibiotic-steroid group (p = 0.05). Among the other secondary outcomes there were no significant differences between the 2 groups. CONCLUSIONS: No benefit was demonstrated in our primary outcome for using steroids in combination with antibiotic therapy in treatment of corneal ulcers. This study suggests that the early addition of steroids to the antibiotic treatment of corneal ulcers does not seem to be harmful when employed in a closely monitored clinical setting. |
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Authors:
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Jason Blair; William Hodge; Saeed Al-Ghamdi; Rita Balabanian; Beth Lowcock; Yi Irene Pan; Hesham Sherif; Tahra AlMahmoud; Dean Fergusson; Allan Slomovic |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie Volume: 46 ISSN: 0008-4182 ISO Abbreviation: Can. J. Ophthalmol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-01 Completed Date: 2011-03-23 Revised Date: 2013-04-24 |
Medline Journal Info:
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Nlm Unique ID: 0045312 Medline TA: Can J Ophthalmol Country: Canada |
Other Details:
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Languages: eng Pagination: 40-5 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University of Ottawa, Ottawa, Ont. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Bacterial Agents / therapeutic use* Bacteria / isolation & purification Corneal Ulcer / drug therapy*, microbiology Dexamethasone / therapeutic use Double-Blind Method Drug Therapy, Combination Eye Infections, Bacterial / drug therapy*, microbiology Female Fluoroquinolones / therapeutic use Glucocorticoids / therapeutic use* Humans Male Middle Aged Quality of Life Visual Acuity / physiology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Fluoroquinolones; 0/Glucocorticoids; 50-02-2/Dexamethasone; L4618BD7KJ/gatifloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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