| Comparison of the anti-Ro/SSA autoantibody profile between patients with primary and secondary Sjögren's syndrome. | |
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MedLine Citation:
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PMID: 11078154 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To measure serum levels of anti-Ro52-kD/SSA, anti-Ro60-kD/SSA and anti-La/SSB autoantibodies in patients with primary and secondary Sjögren's syndrome. To examine if there is any connection between the disease and the subtype-spectrum of these antibodies. METHODS: We measured serum levels of anti-Ro52-kD/SSA, anti-Ro60-kD/SSA and anti-La/SSB autoantibodies by ELISA, in the sera of patients with primary Sjögren's syndrome with or without extraglandular manifestations and with or without anti-La/SSB positivity and of patients with systemic lupus erythematosus/Sjögren's syndrome overlapping disease with or without anti-La/SSB positivity. RESULTS: Differences of the distribution of the anti-Ro52-kD/SSA and the anti-Ro60-kD/SSA were found between the primary and secondary Sjögren's syndrome patients' groups; when Sjögren's syndrome is accompanied by systemic lupus erythematosus, the occurrence of anti-Ro60-kD/SSA autoantibodies is significantly higher than in primary Sjögren'syndrome. CONCLUSION: Our results suggest that there is a possible connection between the distribution of the subtypes of the anti-Ro/SSA autoantibodies and the disease type in primary/secondary Sjögren's syndrome. |
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Authors:
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I Gál; G Lakos; M Zeher |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Autoimmunity Volume: 32 ISSN: 0891-6934 ISO Abbreviation: Autoimmunity Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2001-03-06 Completed Date: 2001-05-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8900070 Medline TA: Autoimmunity Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 89-92 Citation Subset: IM |
Affiliation:
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3rd Department of Internal Medicine and Clinical Immunology, Medical University School of Debrecen Debrecen, Móricz, Hungary. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Antinuclear
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blood* Humans Lupus Erythematosus, Systemic / complications, immunology Sjogren's Syndrome / classification, complications, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antinuclear; 0/SS-A antibodies; 0/SS-B antibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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