Document Detail

Comparison of the anti-anginal efficacy of nicardipine and nifedipine in patients receiving atenolol: a randomized, double-blind, crossover study.
MedLine Citation:
PMID:  2651328     Owner:  NLM     Status:  MEDLINE    
The effects of oral nicardipine (40 mg) and nifedipine (20 mg) in combination with atenolol (100 mg) were compared with those of placebo, oral nitroglycerin (0.4 mg) and atenolol alone (100 mg) in 17 patients with stable effort angina. Patients performed symptom-limited, multistage, upright bicycle ergometric exercises with computer-assisted ECG analysis in bipolar lead CM5. Nicardipine and nifedipine were given double blind and in randomized order. In comparison with placebo (4818 +/- 2021 kpm), patients exercised longer and with a greater work load with nitroglycerin (5748 +/- 1711 kpm, P less than 0.001), the combinations of atenolol and nifedipine (6120 +/- 2274 kpm, P less than 0.05), and atenolol and nicardipine (6671 +/- 2339 kpm, P less than 0.01), but not with atenolol alone (5305 +/- 1524 kpm, P = NS). The magnitude of ST-segment depression at peak exercise with placebo (3.22 +/- 1.72 mm) was dramatically reduced with nitroglycerin (1.39 +/- 1.87 mm) but less with atenolol alone (2.95 +/- 1.83 mm, P less than 0.05) or the combinations of atenolol and nicardipine (3.05 +/- 1.51 mm, P = NS), and atenolol and nifedipine (2.45 +/- 1.25 mm, P less than 0.001). Compared to the combination of atenolol and nifedipine, that of atenolol and nicardipine produced a significantly (P less than 0.05) greater exercise tolerance (6671 +/- 2339 versus 6120 +/- 2274 kpm) but with a greater ST-segment depression at peak exercise (3.05 +/- 1.51 versus 2.45 +/- 1.29 mm, P less than 0.01).
H Douard; B Mora; J P Broustet
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of cardiology     Volume:  22     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-05-26     Completed Date:  1989-05-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  357-63     Citation Subset:  IM    
Hôpital Cardiologique du Haut Leveque, Pessac, France.
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MeSH Terms
Angina Pectoris / drug therapy*
Atenolol / pharmacology,  therapeutic use*
Blood Pressure / drug effects
Clinical Trials as Topic
Double-Blind Method
Drug Synergism
Exercise Test
Heart Rate / drug effects
Middle Aged
Nicardipine / pharmacology,  therapeutic use*
Nifedipine / pharmacology,  therapeutic use*
Random Allocation
Reg. No./Substance:
21829-25-4/Nifedipine; 29122-68-7/Atenolol; 55985-32-5/Nicardipine

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