Document Detail

Comparison of ankle-brachial pressure index and pulse wave velocity as markers of the presence of coronary artery disease in subjects with a high risk of atherosclerotic cardiovascular disease.
MedLine Citation:
PMID:  15464667     Owner:  NLM     Status:  MEDLINE    
Recently, a measurement device that can simultaneously measure the ankle-brachial pressure index (ABI) and brachial-ankle pulse wave velocity (PWV) has become available. The present study compares the applicability of ABI and PWV as markers for predicting the prevalence of coronary artery disease (CAD) in subjects with a high risk of atherosclerotic cardiovascular disease. The ABI and brachial-ankle PWV were measured in 472 consecutive subjects who subsequently underwent coronary angiography for diagnosis or exclusion of CAD. The prevalence of CAD in the lowest ABI quartile was higher than those in the other 3 ABI quartiles, whereas the prevalence in the lowest brachial-ankle PWV quartile was lower than those in the other 3 brachial-ankle PWV quartiles. A multivariate logistic regression analysis demonstrated that the lowest ABI quartile was a significant independent variable for the prevalence of CAD and that the lowest brachial-ankle PWV quartile was a significant independent variable for the absence of CAD in a population. Thus, a low ABI is an independent marker for an additive risk of CAD, whereas a low brachial-ankle PWV may be used as an independent marker for excluding the risk of CAD among subjects with a high risk of atherosclerotic cardiovascular disease.
Yutaka Koji; Hirofumi Tomiyama; Hiroaki Ichihashi; Tsuneyuki Nagae; Nobuhiro Tanaka; Kenji Takazawa; Shin Ishimaru; Akira Yamashina
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  94     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-06     Completed Date:  2004-11-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  868-72     Citation Subset:  AIM; IM    
Second Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan.
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MeSH Terms
Aged, 80 and over
Ankle / blood supply*,  radiography,  ultrasonography
Blood Flow Velocity / physiology*
Blood Pressure / physiology*
Brachial Artery / physiopathology,  radiography,  ultrasonography
Cardiovascular Diseases / diagnosis,  epidemiology,  physiopathology
Coronary Angiography
Coronary Artery Disease / diagnosis,  epidemiology*,  physiopathology*
Echocardiography, Doppler
Follow-Up Studies
Heart Rate / physiology*
Japan / epidemiology
Middle Aged
Multivariate Analysis
Risk Factors
Tibial Arteries / physiopathology,  radiography,  ultrasonography

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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