| Comparison of anidulafungin's and fluconazole's in vivo activity in neutropenic and non-neutropenic models of invasive candidiasis. | |
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MedLine Citation:
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PMID: 22128831 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Clin Microbiol Infect ABSTRACT: We compared the rate and extent of anidulafungin's and fluconazole's activity in neutropenic and non-neutropenic mice with Candida albicans invasive candidiasis. In immunocompetent mice, anidulafungin significantly improved survival vs. controls and fluconazole, and significant reductions in (1→3)-β-D-glucan and fungal burden were observed. In neutropenic animals, the highest doses of anidulafungin (5 mg/kg) and fluconazole (10 mg/kg) also improved survival and reduced fungal burden. However, there were no differences in survival between these antifungals as anidulafungin's activity was attenuated in this model. These results demonstrate that the extent of anidulafungin in vivo efficacy may be dependent on host immune status. |
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Authors:
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N P Wiederhold; L K Najvar; R Bocanegra; W R Kirkpatrick; T F Patterson |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-2 |
Journal Detail:
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Title: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases Volume: - ISSN: 1469-0691 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9516420 Medline TA: Clin Microbiol Infect Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases. |
Affiliation:
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University of Texas at Austin College of Pharmacy, Austin, TX University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases South Texas Veterans Health Care System, San Antonio, TX, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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