Document Detail


Comparison of angiotensin II type 1-receptor blockers to regress pressure overload-induced cardiac hypertrophy in mice.
MedLine Citation:
PMID:  20944638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Angiotensin II (AngII) type 1-receptor blockers (ARBs) have been effectively used not only in the treatment of hypertension but also in cardiac protection. However, whether and why there are differences in these effects still remain unclear. Here we compared the effects of five commonly used ARBs (Candesartan, Olmesartan, Losartan, Telmisartan and Valsartan) on pressure overload-induced cardiac hypertrophy in mice model. Pressure overload was produced by constriction of the transverse aorta (TAC) for 2 weeks, which induced a significant elevation of blood pressure; ARBs or saline was administered through a stomach tube; Cardiac hypertrophy was evaluated by transthoracic echocardiography, cardiac histology and specific gene expression analyses. Although all the five ARBs, which did not repress the elevation of left ventricular pressure after TAC, attenuated the development of cardiac hypertrophy in the wild-type mice, the degrees of regression by Candesartan, Olmesartan and Losartan tended to be larger than those by Telmisartan and Valsartan. Furthermore, in angiotensinogen-knockout mice lacking endogenous AngII, TAC-induced cardiac hypertrophy was regressed by Candesartan, Olmesartan and Losartan but not by Telmisartan and Valsartan administration. Our data suggest that Candesartan, Olmesartan and Losartan can effectively inhibit pressure overload-induced cardiac hypertrophy even in the absence of AngII, whereas Telmisartan and Valsartan could exert the inhibitory effects only in the presence of AngII.
Authors:
Lei Li; Ning Zhou; Hui Gong; Jian Wu; Li Lin; Issei Komuro; Junbo Ge; Yunzeng Zou
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-14
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  33     ISSN:  1348-4214     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-06     Completed Date:  2011-03-18     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1289-97     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Angiotensin II Type 1 Receptor Blockers / pharmacology,  therapeutic use*
Animals
Aorta, Thoracic / physiopathology
Atrial Natriuretic Factor / genetics,  metabolism
Benzimidazoles / therapeutic use
Benzoates / therapeutic use
Blood Pressure / drug effects*
Cardiomegaly / drug therapy*,  genetics,  metabolism,  physiopathology
Echocardiography
Gene Expression
Hemodynamics
Imidazoles / therapeutic use
Losartan / therapeutic use
Male
Mice
Myocardium / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Tetrazoles / therapeutic use
Treatment Outcome
Valine / analogs & derivatives,  therapeutic use
Chemical
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Benzimidazoles; 0/Benzoates; 0/Imidazoles; 0/Tetrazoles; 137862-53-4/valsartan; 85637-73-6/Atrial Natriuretic Factor; 8W1IQP3U10/olmesartan; HG18B9YRS7/Valine; JMS50MPO89/Losartan; S8Q36MD2XX/candesartan; U5SYW473RQ/telmisartan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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