Document Detail

Comparison of angiographic methods for the assessment of the extent of experimental anterior myocardial infarction in dog hearts.
MedLine Citation:
PMID:  1975569     Owner:  NLM     Status:  MEDLINE    
Infarction was provoked in the dog by introducing a copper coil into the left anterior descending coronary artery. Eight groups, each of 6 dogs, were studied which received various treatments and were evaluated after 24 hours or 1 week. The anatomical extent of infarction was measured by the triphenyltetrazoliumhydrochloride method; size was evaluated angiographically by the centerline, chord and radial method and by ejection fraction. The extent of infarction was similar in groups studied after 24 hours and 1 week. Angiographical changes were most marked after 24 hours, and the ejection fraction was related to the extent of infarction (r = -0.5; P less than 0.02). Some parameters of the radial and centerline method showed also a relation to the extent of infarction (r = 0.47 to 0.57; P less than 0.05). After one week, the ejection fraction was no longer correlated to the extent of infarction. The correlation between the parameters of the chord, radius and centerline method and the extent of infarction improved to r-values of 0.58 to 0.63 (P less than or equal to 0.01). There was no difference between the 3 methods.
I K Jang; F van de Werf; J Vanhaecke; A Aubert; H De Geest
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  28     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-10-09     Completed Date:  1990-10-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  179-90     Citation Subset:  IM    
Department of Cardiology, University Hospital Gasthuisberg, Leuven, Belgium.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use
Angiography / methods*
Angiography, Digital Subtraction / methods
Cineangiography / methods
Contrast Media
Diatrizoate / diagnostic use
Diatrizoate Meglumine / diagnostic use
Drug Combinations / diagnostic use
Metoprolol / therapeutic use
Myocardial Contraction
Myocardial Infarction / drug therapy,  radiography*
Stroke Volume
Thrombolytic Therapy
Tissue Plasminogen Activator / therapeutic use
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Contrast Media; 0/Drug Combinations; 117-96-4/Diatrizoate; 131-49-7/Diatrizoate Meglumine; 37350-58-6/Metoprolol; 8064-12-8/urovision; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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