Document Detail

Comparison of the aneuploidy frequency in embryos derived from testicular sperm extraction in obstructive and non-obstructive azoospermic men.
MedLine Citation:
PMID:  15142999     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The use of ICSI has been a major breakthrough in the treatment of male infertility. Even azoospermic patients with focal spermatogenesis in the testis (not sufficient to spill over into the ejaculate) may benefit from the technique. Previous reports suggest a higher pregnancy rate after ICSI treatment in patients with obstructive azoospermia (OA) compared to their non-obstructive azoospermia (NOA) counterparts, which could be due to a higher aneuploidy frequency in the embryos of the latter group. We therefore conducted a prospective cohort study to compare the aneuploidy frequency of the screened embryos between the two groups. METHODS: From May 2001 until September 2003, we offered couples with an OA or NOA partner ICSI in combination with preimplantation genetic diagnosis for aneuploidy screening. RESULTS: No difference in age (30.6 and 33.5 years) or stimulation parameters was observed between the two groups; 53 and 60% of the embryos were abnormal in the NOA and OA groups respectively (P = not significant). CONCLUSIONS: The aneuploidy frequency in embryos obtained from NOA as well as OA men is similar and very high, despite the young age of their female partners.
P Platteau; C Staessen; A Michiels; H Tournaye; A Van Steirteghem; I Liebaers; P Devroey
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2004-05-13
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  19     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-28     Completed Date:  2005-01-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  1570-4     Citation Subset:  IM    
Centre for Reproductive Medicine, University Hospital, Dutch-speaking Brussels Free University (Vrije Universiteit Brussel), 1090, Belgium.
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MeSH Terms
Case-Control Studies
Cohort Studies
Embryo, Mammalian / physiology*
Gene Frequency*
Oligospermia / surgery*
Prospective Studies
Sperm Injections, Intracytoplasmic
Tissue and Organ Harvesting*
Comment In:
J Urol. 2005 Apr;173(4):1280   [PMID:  15758781 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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