Document Detail


Comparison of the analgesic potency of xenon and nitrous oxide in humans evaluated by experimental pain.
MedLine Citation:
PMID:  10193287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have compared the analgesic potency of MAC-equivalent concentrations of xenon (10, 20, 30 and 40%) and nitrous oxide (15, 30, 45 and 60%) in humans using a multimodal experimental pain testing and assessment technique. We tested 12 healthy volunteers in a randomized, single-blind, crossover study. The following experimental pain tests were used: nociceptive reflex to repeated stimuli; pain tolerance to maximal effort tourniquet ischaemia; electrical stimulation; mechanical pressure; and cold. Reaction time was also measured. Xenon and nitrous oxide produced analgesia to ischaemic, electrical and mechanical stimulation, but not to cold pain. There was no difference in MAC-equivalent concentrations of xenon and nitrous oxide. Both increased reaction time in a similar manner. Xenon and nitrous oxide evoked nausea and vomiting in a large number of volunteers.
Authors:
S Petersen-Felix; M Luginbühl; T W Schnider; M Curatolo; L Arendt-Nielsen; A M Zbinden
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  81     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-04-20     Completed Date:  1999-04-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  742-7     Citation Subset:  IM    
Affiliation:
Department of Anaesthesiology and Intensive Care, University Hospital of Bern, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Analgesics, Non-Narcotic / therapeutic use*
Anesthetics, Inhalation / therapeutic use*
Cross-Over Studies
Female
Humans
Male
Nitrous Oxide / therapeutic use*
Pain / prevention & control*
Pain Measurement
Physical Stimulation / methods
Reaction Time / drug effects
Single-Blind Method
Xenon / therapeutic use*
Chemical
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 0/Anesthetics, Inhalation; 10024-97-2/Nitrous Oxide; 7440-63-3/Xenon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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