Document Detail

Comparison of amyloid deposits and infiltration of enteric nervous system in the upper with those in the lower gastrointestinal tract in patients with familial amyloidotic polyneuropathy.
MedLine Citation:
PMID:  11585246     Owner:  NLM     Status:  MEDLINE    
Gastrointestinal (GI) complications in familial amyloidotic polyneuropathy (FAP) are invariably present during the course of the disease. The aim of this study was to investigate amyloid deposits in the myenteric plexus of the stomach and small intestine in FAP patients and compare the results with those of the colon. Six FAP patients were included in the study. The myenteric plexus and the number of macrophages (CD68) and blood vessels were immunostained and quantified by computerised image analysis. Double staining for amyloid and nerve elements was used to detect amyloid infiltration in the myenteric plexus. Amyloid was found predominantly in the walls of blood vessels, and was detected in the nerves of five FAP patients and in 18% of the examined ganglia of the myenteric plexus of the stomach. In the small intestine, 6% of examined ganglia showed amyloid deposits. In contrast, no deposits were found in the myenteric plexus of the colon. CD68-positive cells showed no difference in three parts of the GI tract. Most amyloid deposits were noted in the stomach, followed by the small intestine. There are significantly more blood vessels in the stomach and small intestine compared with the colon, and the amount of amyloid correlated with the number of blood vessels, and not with the amount of nerves and ganglia. The enteric nerve system is not a targeted organ for amyloid deposition in FAP.
I Anan; M El-salhy; Y Ando; H Terazaki; O B Suhr
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neuropathologica     Volume:  102     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-10-04     Completed Date:  2002-01-24     Revised Date:  2007-11-09    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  227-32     Citation Subset:  IM    
Department of Medicine, Gastroenterology section, Umeå University Hospital, Sweden.
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MeSH Terms
Amyloid / analysis*
Amyloid Neuropathies, Familial / complications,  pathology*
Blood Vessels / pathology
Colon / blood supply,  pathology*
Ganglia, Autonomic / blood supply,  pathology
Gastrointestinal Diseases / etiology,  pathology
Image Processing, Computer-Assisted
Intestine, Small / blood supply,  pathology*
Macrophages / pathology
Middle Aged
Myenteric Plexus / blood supply,  pathology*
Stomach / blood supply,  pathology*
Reg. No./Substance:

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