Document Detail

Comparison among intrathecal fentanyl, meperidine, and sufentanil for labor analgesia.
MedLine Citation:
PMID:  1416127     Owner:  NLM     Status:  MEDLINE    
This study compared the analgesic efficacy of intermittent injections of intrathecal fentanyl (10 micrograms), meperidine (10 mg), or sufentanil (5 micrograms) administered to 65 parturients during the first stage of labor. The groups did not differ in onset or duration of effective analgesia. The meperidine group, however, had significantly lower pain scores once cervical dilation progressed beyond 6 cm. Side effects included mild pruritus and nausea. After intrathecal drug injection, variable decelerations of the fetal heart rate increased in the fentanyl and meperidine groups. All neonates had a 5-min Apgar score of 7 or more. We conclude that intermittent intrathecal injections of fentanyl, meperidine, or sufentanil can provide adequate first-stage labor analgesia. Meperidine appears to provide more reliable analgesia as the first stage of labor progresses.
J E Honet; V A Arkoosh; M C Norris; H J Huffnagle; N S Silverman; B L Leighton
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  75     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-11-25     Completed Date:  1992-11-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  734-9     Citation Subset:  AIM; IM    
Department of Anesthesiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
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MeSH Terms
Analgesia, Obstetrical* / adverse effects,  methods
Fentanyl / administration & dosage*
Heart Rate, Fetal / drug effects
Injections, Spinal
Meperidine / administration & dosage*
Sufentanil / administration & dosage*
Reg. No./Substance:
437-38-7/Fentanyl; 56030-54-7/Sufentanil; 57-42-1/Meperidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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