| Comparison of alpha-chloralose, medetomidine and isoflurane anesthesia for functional connectivity mapping in the rat. | |
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MedLine Citation:
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PMID: 20456892 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Functional connectivity measures based upon low-frequency blood-oxygenation-level-dependent functional magnetic resonance imaging (BOLD fMRI) signal fluctuations have become a widely used tool for investigating spontaneous brain activity in humans. Still unknown, however, is the precise relationship between neural activity, the hemodynamic response and fluctuations in the MRI signal. Recent work from several groups had shown that correlated low-frequency fluctuations in the BOLD signal can be detected in the anesthetized rat - a first step toward elucidating this relationship. Building on this preliminary work, through this study, we demonstrate that functional connectivity observed in the rat depends strongly on the type of anesthesia used. Power spectra of spontaneous fluctuations and the cross-correlation-based connectivity maps from rats anesthetized with alpha-chloralose, medetomidine or isoflurane are presented using a high-temporal-resolution imaging sequence that ensures minimal contamination from physiological noise. The results show less localized correlation in rats anesthetized with isoflurane as compared with rats anesthetized with alpha-chloralose or medetomidine. These experiments highlight the utility of using different types of anesthesia to explore the fundamental physiological relationships of the BOLD signal and suggest that the mechanisms contributing to functional connectivity involve a complicated relationship between changes in neural activity, neurovascular coupling and vascular reactivity. |
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Authors:
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Kathleen A Williams; Matthew Magnuson; Waqas Majeed; Stephen M LaConte; Scott J Peltier; Xiaoping Hu; Shella D Keilholz |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-04-24 |
Journal Detail:
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Title: Magnetic resonance imaging Volume: 28 ISSN: 1873-5894 ISO Abbreviation: Magn Reson Imaging Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-09 Completed Date: 2011-01-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8214883 Medline TA: Magn Reson Imaging Country: Netherlands |
Other Details:
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Languages: eng Pagination: 995-1003 Citation Subset: IM |
Affiliation:
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Department of Radiology, Center for Biomedical Imaging, New York University School of Medicine, New York, NY 10012, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics
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administration & dosage Animals Brain / drug effects*, physiology* Brain Mapping / methods* Chloralose / administration & dosage* Isoflurane / administration & dosage* Magnetic Resonance Imaging / methods* Medetomidine / administration & dosage* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics; 15879-93-3/Chloralose; 26675-46-7/Isoflurane; 86347-14-0/Medetomidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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