Document Detail


Comparison of alcoholic cardiomyopathy in women versus men.
MedLine Citation:
PMID:  9285662     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To compare the prevalence and cardiac status of male and female alcoholics with alcoholic cardiomyopathy during a 5-year period, all chronic alcoholics with dilated cardiomyopathy who had clinical symptoms of heart failure were included. Alcoholic cardiomyopathy was diagnosed in 10 chronic alcoholic women and in 26 men; the prevalence of alcoholic cardiomyopathy was similar in both sexes. No significant differences were observed in age, nutritional parameters, and clinical and radiologic data of heart failure between the 2 groups. Alcoholic women reported a significantly lower daily dose of ethanol (p = 0.002), a shorter duration of alcoholism (p = 0.017), and a lower total lifetime dose of ethanol consumption (p = 0.001), and had a lower New York Heart Association functional class than men. Women also had lesser ventricular dysfunction than men. In a multivariate analysis, left ventricular systolic dysfunction was related to the total lifetime dose of ethanol consumption (p <0.04), but not to gender. Finally, when patients were matched for left ventricular ejection fraction, women had consumed a lower total lifetime dose of ethanol than men (p <0.001). The prevalence of alcoholic women with dilated cardiomyopathy was found to be similar to that of alcoholic men, although women required a lower total lifetime dose of ethanol to develop the disease.
Authors:
J Fernández-Solà; R Estruch; J M Nicolás; J C Paré; E Sacanella; E Antúnez; A Urbano-Márquez
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  80     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-16     Completed Date:  1997-09-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  481-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Hospital Clínic i Provincial, University of Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cardiomyopathy, Alcoholic / blood,  physiopathology*
Cardiomyopathy, Dilated / blood,  chemically induced*,  physiopathology*
Dose-Response Relationship, Drug
Ethanol / adverse effects*
Female
Heart / drug effects*,  physiopathology
Humans
Male
Middle Aged
Multivariate Analysis
Prevalence
Sex Characteristics
Chemical
Reg. No./Substance:
64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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