| Comparison of afferent and efferent lung lymph in the sheep. | |
| | |
MedLine Citation:
|
PMID: 3403418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Efferent lymph collected from the caudal mediastinal lymph node (CMN) in the sheep lung lymph fistula model has been reported to represent free pulmonary interstitial fluid. Studies that utilize this model assume that nodal transit does not alter the composition of lymph. We collected afferent lymph from the tracheobronchial node (TBN) while simultaneously collecting CMN efferent lymph in acutely prepared sheep. We compared afferent and efferent lymph protein concentrations (CA and CE) and changes in flow rates (QLA and QLE) during base line and periods of elevated left atrial pressure (Pla). As a result of elevated Pla, QLA and QLE increased and the afferent lymph-to-plasma protein concentration ratio (CA/Cp) and the efferent lymph-to-plasma protein concentration ratio (CE/Cp) fell. The CA/Cp was significantly lower than the CE/Cp during base line (0.67 vs. 0.80) and periods of elevated Pla (0.41 vs. 0.61). Although we cannot exclude regional permeability differences, the difference between CA/Cp and CE/Cp is most likely due to the concentration of lymph within the CMN. Our data suggest nodal modification of CA is correlated with the afferent lymph-to-plasma colloid osmotic pressure ratio (pi A/pi p) and further suggest that nodal alteration of lymph during elevated Pla is due to the influence of decreased pi A/pi p at the blood-to-lymph barrier. We conclude that afferent lymph is a more accurate representation of lung free interstitial fluid because collection of pulmonary afferent lymph obviates the complications introduced by the CMN. Studies utilizing efferent lymph may have overestimated lung microvascular permeability in the acute sheep preparation. |
| | |
Authors:
|
D E McClure; W J Weidner |
Related Documents
:
|
1292888 - Comparison of the pulmonary lymphatic and hemodynamic changes of near-drowning in a she... 12644728 - Isoprostane 8-epi-prostaglandin f2 alpha decreases lymph capillary pressure in patients... 2012238 - Effect of outflow pressure on intestinal lymph flow in unanesthetized sheep. 11557548 - Distribution spaces for hyaluronan and albumin in rat tail tendons. 22100298 - Hemodynamic efficacy of the over-the-scope clip in an established porcine cadaveric mod... 12817188 - Fasting blood glucose is independently associated with resting and exercise blood press... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 64 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1988 Jun |
Date Detail:
|
Created Date: 1988-09-21 Completed Date: 1988-09-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 2340-7 Citation Subset: IM |
Affiliation:
|
Department of Animal Physiology, University of California, Davis 95616. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure Blood Proteins / analysis Lung / physiology* Lymph / physiology* Lymphatic System / physiology* Proteins / analysis Pulmonary Circulation Sheep / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Blood Proteins; 0/Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relationship of muscular fatigue to pH and diprotonated Pi in humans: a 31P-NMR study.
Next Document: Assessment of tight junctions between pulmonary epithelial and endothelial cells.