Document Detail

Comparison of adrenal vein sampling value between aldosterone producing adrenal adenoma and non-functioning adrenal adenoma: evaluation using receiver operating characteristic analysis.
MedLine Citation:
PMID:  16372697     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate adequate criteria for adrenal vein sampling values in patients with aldosterone producing adrenal adenoma (APA), retrospectively. MATERIAL AND METHODS: Between 1988 and 2002, 59 hypertensive patients (15 M and 44 F, aged 47.58 +/- 9.45 years) were referred to our hospital and diagnosed with APA based on established criteria. During the same period, 23 patients with non-functioning adrenal adenoma (11 M and 12 F aged 53.56 +/- 11.76 years) were diagnosed based on computed tomography and laboratory data. RESULTS: All 82 patients were enrolled in the present study. Bilateral adrenal vein sampling (AVS) for measurement of plasma aldosterone (A) and cortisol (C) was performed, and a receiver operating characteristics (ROC) analysis was conducted to establish the best criteria from the AVS-derived index in patients with APA. A (APA side)/A (contralateral side) was confirmed to provide the best diagnostic accuracy {(>2.5: right APA, sensitivity 83.3%, specificity 79.5%), (> 3: left APA, sensitivity 84.2%, specificity 76.9)}. The Az values for A (APA side)/A (contralateral side) were 0.8948 and 0.9260 for right and left APA, respectively. CONCLUSION: The A (APA side)/A (contralateral side) value was the best compromise for sensitivity and false-positive rate for lateralization of APA.
Y Baba; H Hokotate; M Nakajo
Related Documents :
24165787 - Lung cancer screening with low-radiation dose computed tomography after liver transplan...
25121587 - Black and white women in maryland receive different treatment for cervical cancer.
16897267 - Comparison of contrast-enhanced ultrasound and computed tomography in classifying endol...
24581527 - Population-based comparative effectiveness of salvage radical prostatectomy vs cryother...
22589487 - Using germline genomics to individualize pediatric cancer treatments.
8834577 - Complete parietal and visceral peritonectomy of the pelvis for advanced primary and rec...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  46     ISSN:  0284-1851     ISO Abbreviation:  Acta Radiol     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-12-23     Completed Date:  2006-01-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  750-5     Citation Subset:  IM    
Department of Radiology, Faculty of Medicine, Kagoshima University, Kagoshima, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenoma / diagnosis*
Adrenal Gland Neoplasms / diagnosis*
Adrenal Glands / blood supply*
Aldosterone / blood*
False Positive Reactions
Functional Laterality
Hydrocortisone / blood*
Hyperaldosteronism / etiology*
Middle Aged
ROC Curve*
Sensitivity and Specificity
Reg. No./Substance:
50-23-7/Hydrocortisone; 52-39-1/Aldosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ultrasound guidance in intracranial tumor resection: correlation with postoperative magnetic resonan...
Next Document:  Low-dose and standard-dose unenhanced helical computed tomography for the assessment of acute renal ...