| Comparison of adenosine, isoflurane, and desflurane on myocardial tissue oxygen pressure during coronary artery constriction in dogs. | |
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MedLine Citation:
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PMID: 12968239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare adenosine-, isoflurane-, or desflurane-induced hypotension with and without left anterior descending (LAD) coronary artery constriction for the effects on myocardial tissue oxygen pressure (PmO(2)) in dogs. DESIGN: Prospective, randomized, nonblinded. SETTING: University teaching hospital. PARTICIPANTS: Male nonpurpose-bred dogs (n = 18). INTERVENTIONS: Dogs were anesthetized with 1.5% isoflurane (n = 12) or 8% desflurane (n = 6). A flow probe and balloon occluder were placed on the LAD artery. A probe that measured myocardial oxygen pressure was inserted into the middle myocardium in the LAD region. Myocardial oxygen consumption (MVO(2)) was calculated as LAD flow x arterial minus coronary sinus oxygen content. MEASURES AND MAIN RESULTS: Measures were made during hypotension produced by adenosine infusion, 2.8% isoflurane, or 14% desflurane with and without LAD constriction to decrease blood flow 30%. Without LAD artery constriction, adenosine infusion increased LAD flow 90% and MVO(2) 70%, 2.8% isoflurane produced no change in MVO(2), and 14% desflurane decreased MVO(2) 25%, but no treatment changed PmO(2). LAD artery constriction decreased PmO(2) 50% by itself. Adenosine infusion during LAD constriction decreased tissue oxygen pressure an additional 60%, 2.8% isoflurane produced no change, and 14% desflurane increased PmO(2) 100%. CONCLUSION: There was an inverse relationship between the effect of adenosine, 2.8% isoflurane, and 14% desflurane on MVO(2) and PmO(2) during ischemia. This is consistent with reports that increasing oxygen demand worsens myocardial ischemia. |
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Authors:
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William E Hoffman; Ronald F Albrecht; Zivojin S Jonjev |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of cardiothoracic and vascular anesthesia Volume: 17 ISSN: 1053-0770 ISO Abbreviation: J. Cardiothorac. Vasc. Anesth. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-09-11 Completed Date: 2004-01-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9110208 Medline TA: J Cardiothorac Vasc Anesth Country: United States |
Other Details:
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Languages: eng Pagination: 495-8 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Physiology, University of Illinois at Chicago, Chicago, IL 60612, USA. whoffman@uic.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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pharmacology* Animals Blood Pressure / drug effects* Carbon Dioxide / metabolism Constriction, Pathologic / metabolism* Coronary Circulation / drug effects Coronary Stenosis / metabolism* Disease Models, Animal Dogs Heart Rate / drug effects Hypotension / chemically induced, metabolism Isoflurane / analogs & derivatives*, pharmacology* Male Models, Cardiovascular Myocardium / metabolism* Oxygen / metabolism* Oxygen Consumption / drug effects Prospective Studies Random Allocation Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 124-38-9/Carbon Dioxide; 26675-46-7/Isoflurane; 57041-67-5/desflurane; 58-61-7/Adenosine; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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