Document Detail

Comparison of adenosine echocardiography, with and without isometric handgrip, to exercise echocardiography in the detection of ischemia in patients with coronary artery disease.
MedLine Citation:
PMID:  8679235     Owner:  NLM     Status:  MEDLINE    
This study was undertaken to evaluate whether adenosine echocardiography is comparable to exercise echocardiography in the detection of ischemia in patients with suspected coronary artery disease and to assess whether the addition of handgrip exercise to adenosine enhances the induction of ischemia in these patients. Accordingly, 67 patients with suspected or known coronary artery disease referred for exercise testing underwent adenosine, adenosine with handgrip, and post-treadmill exercise echocardiography. A maximal adenosine infusion dose of 170 micrograms/kg/min was used. Images at baseline and during each of the three stress modalities were digitized in a quad-screen format, randomized, and blinded as to the stage and mode of intervention for nonbiased interpretation. An ischemic response was defined as a new or worsening wall motion abnormality. Ischemia was detected by exercise echocardiography (n = 20) more often than by adenosine echocardiography alone (n = 11; p = 0.039) but similarly to adenosine plus handgrip (n = 16; difference not significant). Exact agreement in individual response between exercise adenosine echocardiography was seen in 51 (80%) of 64 patients and increased to 88% between exercise and adenosine plus handgrip. In the patients who underwent angiography (n = 45), the sensitivity for coronary artery disease (n = 33) was 87% for adenosine, 91% for adenosine plus handgrip, and 93% for exercise echocardiography. The respective sensitivities decreased to 64%, 81%, and 89% in patients without previous myocardial infarction. Specificity was 91% for adenosine with or without handgrip and 82% for exercise echocardiography. Image quality during adenosine with and without handgrip was superior to that during exercise (p < 0.01). Thus in patients with coronary artery disease able to exercise, exercise echocardiography induces ischemia more frequently than does adenosine echocardiography alone. The addition of handgrip exercise to adenosine infusion enhances the detection of ischemia without reducing specificity or image quality and is recommended when adenosine echocardiography is used as a pharmacologic stress test.
C B Tawa; W B Baker; N S Kleiman; A Trakhtenbroit; R Desir; W A Zoghbi
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  9     ISSN:  0894-7317     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:    1996 Jan-Feb
Date Detail:
Created Date:  1996-08-22     Completed Date:  1996-08-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  33-43     Citation Subset:  IM; S    
Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
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MeSH Terms
Adenosine / diagnostic use*
Cardiovascular Agents / diagnostic use*
Coronary Angiography
Coronary Disease / radiography,  ultrasonography*
Exercise Test
Hand / physiology*
Image Enhancement
Image Processing, Computer-Assisted
Infusions, Intravenous
Isometric Contraction*
Middle Aged
Myocardial Ischemia / radiography,  ultrasonography*
Physical Exertion*
Prospective Studies
Sensitivity and Specificity
Single-Blind Method
Grant Support
Reg. No./Substance:
0/Cardiovascular Agents; 58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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