Document Detail

Comparison of the acute hemodynamic effects of intravenous celiprolol and propranolol in patients with suspected coronary disease.
MedLine Citation:
PMID:  2427857     Owner:  NLM     Status:  MEDLINE    
The acute hemodynamic effects of intravenously administered celiprolol and propranolol were compared in 18 patients, 12 with coronary obstruction in the presence or absence of reduced LV function and six with no significant cardiac disease. The study was performed using a single blind, randomized design with celiprolol (0.07 and 0.14 mg/kg) and propranolol (0.07 mg/kg) in six patients per treatment group. The hemodynamic parameters obtained via right and left heart catheterization were measured at baseline and at 5 and 10 min after drug infusion (1.0 mg/min). Propranolol produced a significant fall in left ventricular Vmax, left ventricular dP/dt and cardiac output. In contrast, celiprolol either caused no change or significantly increased these parameters. These results indicate that celiprolol has an acute hemodynamic profile which differs significantly from that of propranolol.
G Gensini; C Dator; P Esente; F S Caruso; T Solomon
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  8 Suppl 4     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1986  
Date Detail:
Created Date:  1986-10-20     Completed Date:  1986-10-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S83-5     Citation Subset:  IM    
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MeSH Terms
Coronary Disease / drug therapy*
Heart Catheterization
Hemodynamics / drug effects*
Middle Aged
Propanolamines / therapeutic use*
Propranolol / therapeutic use*
Reg. No./Substance:
0/Propanolamines; 525-66-6/Propranolol; 56980-93-9/Celiprolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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