| Comparison of the acute hemodynamic and coronary vasodilating effects between nicorandil and glyceryl trinitrate. | |
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MedLine Citation:
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PMID: 1834065 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute hemodynamic and coronary vasodilating effects of nicorandol (SG-75, Sigmat; CAS 65141-46-0) and glyceryl trinitrate (GTN, nitroglycerin) were examined in 20 subjects under cardiac catheterization and coronary arteriography. Nicorandil 4 mg i.v. produced significant increases in heart rate, cardiac index and stroke volume index and significant decreases in systolic, diastolic and mean blood pressure, pulmonary capillary wedge pressure, left ventricular enddiastolic pressure, systemic vascular resistance and total pulmonary resistance. Degree of percent changes in these parameters by nicorandil were similar to that by GTN 0.3 mg i.v. Coronary vasodilating effects of both drugs were also at the same degree. Results indicate that nicorandil has cardiovascular and coronary vasodilating effects similar to those of GTN when administered intravenously. |
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Authors:
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T Chibana; F Nagamine; R Sunagawa; K Oshiro; Y Nakada; M Shimabukuro; T Shinzato; K Murakami; G Mimura; M Sakanashi |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 41 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1991 Jun |
Date Detail:
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Created Date: 1991-11-05 Completed Date: 1991-11-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY |
Other Details:
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Languages: eng Pagination: 591-4 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, School of Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / drug effects Cardiac Output / drug effects Coronary Circulation / drug effects* Female Heart Rate / drug effects Hemodynamics / drug effects* Humans Male Middle Aged Niacinamide / analogs & derivatives*, pharmacology Nicorandil Nitroglycerin / pharmacology* Pulmonary Circulation / drug effects Stroke Volume / drug effects Vascular Resistance / drug effects Vasodilation / drug effects* Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 55-63-0/Nitroglycerin; 65141-46-0/Nicorandil; 98-92-0/Niacinamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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