Document Detail

Comparison of the acute and chronic hemodynamic effects of captopril and guanethidine in spontaneously hypertensive rats.
MedLine Citation:
PMID:  6998684     Owner:  NLM     Status:  MEDLINE    
The present study compared the hemodynamic effects of captopril with those of guanethidine as well as with a combination of these two drugs in conscious male spontaneously hypertensive rats. Acutely, captopril or guanethidine or a combination of the two lowered arterial pressure to similar levels. The reduction in pressure with captopril alone or in combination with guanethidine, was due to a lowering of all organ vascular resistances. Guanethidine alone lowered pressure by reducing cardiac output. Chronically, captopril or guanethidine lowered arterial pressure to similar levels by reducing organ vascular resistances to comparable levels, particularly skeletal muscle, skin and splanchnic organs. Combination of these two drugs had an additive effect on the reduction of arterial pressure and organ vascular resistances. Since, chronically, the addition of guanethidine to captopril therapy enhanced rather than attenuated the hemodynamic changes induced by captopril, these drugs are probably acting by different mechanisms and the mechanisms of action of captopril does not require an intact sympathetic nervous system.
R A Ferrone; C L Heran; M J Antonaccio
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension     Volume:  2     ISSN:  0148-3927     ISO Abbreviation:  Clin Exp Hypertens     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-12-18     Completed Date:  1980-12-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7803060     Medline TA:  Clin Exp Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  247-72     Citation Subset:  IM    
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MeSH Terms
Blood Circulation / drug effects
Blood Pressure / drug effects*
Captopril / administration & dosage,  pharmacology*
Cardiac Output / drug effects
Guanethidine / administration & dosage,  pharmacology*
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypertension / physiopathology*
Proline / analogs & derivatives*
Regional Blood Flow / drug effects
Time Factors
Vascular Resistance / drug effects
Reg. No./Substance:
147-85-3/Proline; 55-65-2/Guanethidine; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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