| Comparison of activity of alpha-adrenoceptor agonists and antagonists in dog and rabbit saphenous vein. | |
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MedLine Citation:
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PMID: 2864638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The alpha adrenoceptors present on the saphenous vein of the dog and rabbit were characterised in vitro using the selective alpha 1 antagonist prazosin and the alpha 2 antagonists rauwolscine and yohimbine. In the dog saphenous vein, prazosin and rauwolscine competitively antagonised contractile responses to phenylephrine and UK-14,304 respectively. Noradrenaline was competitively blocked by prazosin only. In contrast, phenylephrine and methoxamine-induced responses in the rabbit saphenous vein were insensitive to prazosin and corynanthine. Rauwolscine competitively blocked responses to UK-14,304, noradrenaline and phenylephrine and pA2 values were similar against each agonist. Noradrenaline and UK-14,304 were equipotent agonists on the rabbit saphenous vein while in the dog vein noradrenaline has a lower potency than UK-14,304. These results suggest that the dog saphenous vein has a mixed population of alpha adrenoceptors, while the alpha adrenoceptors on the rabbit vein are homogeneous, with characteristics of the alpha 2 subtype. |
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Authors:
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V A Alabaster; R F Keir; C J Peters |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Naunyn-Schmiedeberg's archives of pharmacology Volume: 330 ISSN: 0028-1298 ISO Abbreviation: Naunyn Schmiedebergs Arch. Pharmacol. Publication Date: 1985 Jul |
Date Detail:
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Created Date: 1985-11-15 Completed Date: 1985-11-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0326264 Medline TA: Naunyn Schmiedebergs Arch Pharmacol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 33-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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pharmacology* Adrenergic alpha-Antagonists / pharmacology* Animals Male Muscle Contraction / drug effects Muscle, Smooth, Vascular / drug effects* Norepinephrine / pharmacology Phenylephrine / pharmacology Prazosin / pharmacology Rabbits Saphenous Vein / drug effects Species Specificity Yohimbine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Adrenergic alpha-Antagonists; 146-48-5/Yohimbine; 19216-56-9/Prazosin; 51-41-2/Norepinephrine; 59-42-7/Phenylephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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