Document Detail


Comparison of activity of alpha-adrenoceptor agonists and antagonists in dog and rabbit saphenous vein.
MedLine Citation:
PMID:  2864638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The alpha adrenoceptors present on the saphenous vein of the dog and rabbit were characterised in vitro using the selective alpha 1 antagonist prazosin and the alpha 2 antagonists rauwolscine and yohimbine. In the dog saphenous vein, prazosin and rauwolscine competitively antagonised contractile responses to phenylephrine and UK-14,304 respectively. Noradrenaline was competitively blocked by prazosin only. In contrast, phenylephrine and methoxamine-induced responses in the rabbit saphenous vein were insensitive to prazosin and corynanthine. Rauwolscine competitively blocked responses to UK-14,304, noradrenaline and phenylephrine and pA2 values were similar against each agonist. Noradrenaline and UK-14,304 were equipotent agonists on the rabbit saphenous vein while in the dog vein noradrenaline has a lower potency than UK-14,304. These results suggest that the dog saphenous vein has a mixed population of alpha adrenoceptors, while the alpha adrenoceptors on the rabbit vein are homogeneous, with characteristics of the alpha 2 subtype.
Authors:
V A Alabaster; R F Keir; C J Peters
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  330     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-11-15     Completed Date:  1985-11-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  33-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / pharmacology*
Adrenergic alpha-Antagonists / pharmacology*
Animals
Male
Muscle Contraction / drug effects
Muscle, Smooth, Vascular / drug effects*
Norepinephrine / pharmacology
Phenylephrine / pharmacology
Prazosin / pharmacology
Rabbits
Saphenous Vein / drug effects
Species Specificity
Yohimbine / pharmacology
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Adrenergic alpha-Antagonists; 146-48-5/Yohimbine; 19216-56-9/Prazosin; 51-41-2/Norepinephrine; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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