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Comparison of Ventricular Radiofrequency Lesions in Sheep Using Standard Irrigated Tip Catheter versus Catheter Ablation Enabling Direct Visualization.
MedLine Citation:
PMID:  22554117     Owner:  NLM     Status:  Publisher    
Comparison of Ventricular Radiofrequency Lesions in Sheep.  Introduction: In vivo assessment of RF ablation lesions is limited. Improved feedback could affect procedural outcome. A novel catheter, IRIS™ Cardiac Ablation Catheter (IRIS), enabling direct tissue visualization during ablation, was compared to a 3.5 mm open-irrigated tip ThermoCool™ Catheter (THERM) for endocardial ventricular RF ablation in sheep.  Methods: Sixteen anesthetized sheep (6 ± 1 years old, 60 ± 10 kg) underwent ventricular RF applications with either the THERM (Biosense Webster) or IRIS (Voyage Medical) ablation catheter. In the THERM group, RF was delivered (30 W, 60 seconds) when electrode contact was achieved as assessed by recording high-amplitude electrogram, tactile feedback, and x-ray. In the IRIS group, direct visualization was used to confirm tissue contact and to guide energy delivery (10-25 W for 60 seconds) depending on visual feedback during lesion formation. Results: A total of 160 RF applications were delivered (80 with THERM; 80 with IRIS). Average power delivery was significantly higher in the THERM group than in the IRIS group (30 ± 2 W [25-30 W] for 57 ± 14 seconds vs 21 ± 4 W [10-25 W] for 57 ± 27 seconds; P<0.001). At necropsy, 62/80 (78%) lesions created with THERM were identified versus 79/80 (99%) with IRIS (P<0.001). The lesion dimensions were not significantly different between THERM and IRIS.  Conclusion: Despite best efforts using standard clinical assessments of catheter contact, 22% of RF applications in the ventricles using a standard open-irrigated catheter could not be identified on necropsy. In vivo assessment of catheter contact by direct visualization of the tissue undergoing RF ablation with the IRIS™ catheter was more reliable by allowing creation of 99% prescribed target lesions without significant complications. (J Cardiovasc Electrophysiol, Vol. pp. 1-5).
Frederic Sacher; Nicolas Derval; Amir Jadidi; Daniel Scherr; Meleze Hocini; Michel Haissaguerre; Pierre Dos Santos; Pierre Jais
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-3
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  -     ISSN:  1540-8167     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Wiley Periodicals, Inc.
University of Bordeaux, Centre de Recherche Cardio-Thoracique de Bordeaux, Bordeaux, France INSERM, Centre de Recherche Cardio-Thoracique de Bordeaux, Bordeaux, France Bordeaux University Hospital, F-33000 Bordeaux, France.
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