Document Detail

Comparison of U-73,975 and cisplatin cytotoxicity in fresh cervical and ovarian carcinoma specimens with the ATP-chemosensitivity assay.
MedLine Citation:
PMID:  1468696     Owner:  NLM     Status:  MEDLINE    
U-73,975 (U-73), a closely related synthetic analogue of the antitumor agent CC-1065, acts by binding tightly in the minor groove of DNA. A comparison was made between the cytotoxicity of U-73 and cisplatin (DDP) on 11 fresh cervical and 7 fresh ovarian carcinoma specimens. The ATP-chemosensitivity assay as previously described (Sevin et al. Gynecol. Oncol. 31, 191-204, 1988) was used to determine the cytotoxic effect of U-73 and DDP. IC 50s were calculated using regression analysis. The mean IC 50s for U-73 and DDP were 519 pg/ml and 2918 ng/ml, respectively, for the cervical carcinoma specimens and 324 pg/ml and 2649 ng/ml, respectively, for the ovarian carcinoma specimens. Significance comparing U-73 and DDP for cervical and ovarian tissue was demonstrated with P < 0.001. U-73 was 4000 times as cytotoxic per unit of mass as DDP on cervical carcinoma compared to over 8000 times for ovarian carcinoma. Based on these in vitro data, U-73 appears to be a very promising antitumor agent for cervical and ovarian carcinoma.
R D Hightower; B U Sevin; J P Perras; M Untch; R Angioli; R Ramos; H Averette
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gynecologic oncology     Volume:  47     ISSN:  0090-8258     ISO Abbreviation:  Gynecol. Oncol.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-01-22     Completed Date:  1993-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0365304     Medline TA:  Gynecol Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  186-90     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Miami School of Medicine, Florida 33101.
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MeSH Terms
Adenosine Triphosphate / analysis*
Antineoplastic Agents / pharmacology*
Cisplatin / pharmacology*
Cyclohexanecarboxylic Acids / pharmacology*
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor / methods
Ovarian Neoplasms / chemistry,  drug therapy*
Regression Analysis
Uterine Cervical Neoplasms / chemistry,  drug therapy*
Reg. No./Substance:
0/Antineoplastic Agents; 0/Cyclohexanecarboxylic Acids; 0/Cyclohexenes; 0/Indoles; 123219-86-3/adozelesin; 15663-27-1/Cisplatin; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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