| Comparison of U-73,975 and cisplatin cytotoxicity in fresh cervical and ovarian carcinoma specimens with the ATP-chemosensitivity assay. | |
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MedLine Citation:
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PMID: 1468696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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U-73,975 (U-73), a closely related synthetic analogue of the antitumor agent CC-1065, acts by binding tightly in the minor groove of DNA. A comparison was made between the cytotoxicity of U-73 and cisplatin (DDP) on 11 fresh cervical and 7 fresh ovarian carcinoma specimens. The ATP-chemosensitivity assay as previously described (Sevin et al. Gynecol. Oncol. 31, 191-204, 1988) was used to determine the cytotoxic effect of U-73 and DDP. IC 50s were calculated using regression analysis. The mean IC 50s for U-73 and DDP were 519 pg/ml and 2918 ng/ml, respectively, for the cervical carcinoma specimens and 324 pg/ml and 2649 ng/ml, respectively, for the ovarian carcinoma specimens. Significance comparing U-73 and DDP for cervical and ovarian tissue was demonstrated with P < 0.001. U-73 was 4000 times as cytotoxic per unit of mass as DDP on cervical carcinoma compared to over 8000 times for ovarian carcinoma. Based on these in vitro data, U-73 appears to be a very promising antitumor agent for cervical and ovarian carcinoma. |
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Authors:
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R D Hightower; B U Sevin; J P Perras; M Untch; R Angioli; R Ramos; H Averette |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gynecologic oncology Volume: 47 ISSN: 0090-8258 ISO Abbreviation: Gynecol. Oncol. Publication Date: 1992 Nov |
Date Detail:
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Created Date: 1993-01-22 Completed Date: 1993-01-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0365304 Medline TA: Gynecol Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 186-90 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Miami School of Medicine, Florida 33101. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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analysis* Antineoplastic Agents / pharmacology* Cisplatin / pharmacology* Cyclohexanecarboxylic Acids / pharmacology* Cyclohexenes Dose-Response Relationship, Drug Drug Screening Assays, Antitumor / methods Female Humans Indoles* Ovarian Neoplasms / chemistry, drug therapy* Regression Analysis Uterine Cervical Neoplasms / chemistry, drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Cyclohexanecarboxylic Acids; 0/Cyclohexenes; 0/Indoles; 123219-86-3/adozelesin; 15663-27-1/Cisplatin; 56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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