Document Detail


Comparison of Travoprost and Bimatoprost plus timolol fixed combinations in open-angle glaucoma patients previously treated with latanoprost plus timolol fixed combination.
MedLine Citation:
PMID:  20688314     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To compare the ocular hypotensive effect of bimatoprost plus timolol and travoprost plus timolol fixed combinations in glaucoma patients whose disease was controlled but had not reached their target intraocular pressure (IOP) with the fixed combination of latanoprost plus timolol. DESIGN: A 2 × 3-month, multicenter, prospective, randomized, double-masked, cross-over clinical trial. METHODS: Eighty-nine open-angle glaucoma (OAG) patients were included. After a 6-week run-in period with latanoprost plus timolol, patients were randomized to either travoprost plus timolol or bimatoprost plus timolol for 3 months. Patients then switched to the opposite therapy for 3 additional months. The primary end point was the comparison of mean daily IOP after 3 months of each treatment. RESULTS: At baseline, mean IOP was 16.5 mm Hg (95% confidence interval, 16.0 to 17.0 mm Hg) with treatment with latanoprost plus timolol. Both bimatoprost plus timolol and travoprost plus timolol statistically significantly reduced the mean IOP from baseline (P < .0001). Mean IOP at month 3 was statistically significantly lower in the bimatoprost plus timolol group compared with the travoprost plus timolol group (14.7 mm Hg [95% confidence interval, 14.3 to 15.3 mm Hg] vs 15.4 mm Hg [95% confidence interval, 15.0 to 15.9 mm Hg]; P = .0041). IOP was lower during bimatoprost plus timolol treatment at all time points and statistical significance was reached at 8 am, 11 am, and 5 pm, but not at 2 pm and 8 pm. Both treatments showed similar tolerability profile. CONCLUSIONS: Bimatoprost plus timolol and travoprost plus timolol can provide additional IOP-lowering effect in patients not fully controlled with latanoprost plus timolol. The observed additional IOP reduction was greater with bimatoprost plus timolol with a similar tolerability profile.
Authors:
Marco Centofanti; Francesco Oddone; Stefano Gandolfi; Anton Hommer; Andreas Boehm; Lucia Tanga; Chiara Sangermani; Vito Sportelli; Michael Haustein; Gianluca Manni; Luca Rossetti
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-08-04
Journal Detail:
Title:  American journal of ophthalmology     Volume:  150     ISSN:  1879-1891     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-24     Completed Date:  2010-10-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  575-80     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Unità Dipartimentale Semplice di Glaucoma, University of Tor Vergata, Rome, Italy; Istituto di Ricovero e Cura a Carattere Scientifico Fondazione G.B. Bietti, Rome, Italy. marco.centofanti@fastwebnet.it
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MeSH Terms
Descriptor/Qualifier:
Aged
Amides / administration & dosage*
Antihypertensive Agents / administration & dosage*
Cloprostenol / administration & dosage,  analogs & derivatives*
Cross-Over Studies
Double-Blind Method
Drug Combinations
Glaucoma, Open-Angle / drug therapy*
Gonioscopy
Humans
Intraocular Pressure / drug effects
Prospective Studies
Prostaglandins F, Synthetic / administration & dosage*
Timolol / administration & dosage*
Tonometry, Ocular
Visual Acuity
Chemical
Reg. No./Substance:
0/Amides; 0/Antihypertensive Agents; 0/Drug Combinations; 0/Prostaglandins F, Synthetic; 0/bimatoprost; 130209-82-4/latanoprost; 157283-68-6/travoprost; 26839-75-8/Timolol; 40665-92-7/Cloprostenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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