| Comparison of Th-cell immunity against human bocavirus and parvovirus B19: proliferation and cytokine responses are similar in magnitude but more closely interrelated with human bocavirus. | |
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MedLine Citation:
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PMID: 21198754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human parvovirus B19 (B19) has been, for decades, the only parvovirus known to be pathogenic in humans. Another pathogenic human parvovirus, human bocavirus (HBoV), was recently identified in respiratory samples from children with acute lower respiratory tract symptoms. Both B19 and HBoV are transmitted by the respiratory route. The vast majority of adults are IgG seropositive for HBoV, whereas the HBoV-specific Th-cell immunity has not much been studied. The aim of this study was to increase our knowledge on HBoV-specific Th-cell immunity by examining HBoV-specific T-cell proliferation, Interferon-gamma (IFN-γ), IL-10 and IL-13 responses in 36 asymptomatic adults. Recombinant HBoV VP2 virus-like particles (VLP) were used as antigen. HBoV-specific responses were compared with those elicited by B19 VP2 VLP. Proliferation, IFN-γ and IL-10 responses with HBoV and B19 antigens among B19-seropositive subjects were statistically similar in magnitude, but the cytokine and proliferation responses were much more closely correlated in HBoV than in B19. Therefore, at the collective level, B19-specific Th-cell immunity appears to be more divergent than the HBoV-specific one. |
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Authors:
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A Kumar; C Filippone; A Lahtinen; L Hedman; M Söderlund-Venermo; K Hedman; R Franssila |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of immunology Volume: 73 ISSN: 1365-3083 ISO Abbreviation: Scand. J. Immunol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-04 Completed Date: 2011-01-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0323767 Medline TA: Scand J Immunol Country: England |
Other Details:
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Languages: eng Pagination: 135-40 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Scandinavian Journal of Immunology © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Virology, Haartman Institute, Helsinki University Central Hospital Laboratory Division, University of Helsinki, Helsinki, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bocavirus / immunology* Cell Proliferation* Cells, Cultured Cytokines / biosynthesis, immunology* Humans Middle Aged Parvovirus B19, Human / immunology* T-Lymphocytes, Helper-Inducer / cytology*, immunology*, virology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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