Document Detail

Comparison of the Tei index with invasive measurements of right ventricular function.
MedLine Citation:
PMID:  16325940     Owner:  NLM     Status:  MEDLINE    
The Doppler-derived Tei index has been reported to be clinically useful in assessing global right ventricular function. It could increase in response to combinations of increased pulmonary artery pressure and/or ventricular dysfunction. We compared the Tei index with invasive measurements of right ventricular function during acute pulmonary hypertension. Right and left ventricular pressures, pulmonary and aortic pressures, pulmonary flow and right ventricular volume by sonomicrometry were measured in six anaesthetized sheep. Graded pulmonary arterial hypertension was induced by a mechanical occlusion maneuver. Pressure-volume loops were generated during preload reduction through caval occlusion. Epicardial echocardiograms were also performed. Invasive indexes including preload recruitable stroke work, ventricular diastolic time constant and stiffness constant, and cardiac output were assessed, as were noninvasive echocardiographic indexes including Tei index and E/A ratio. The right ventricular pressure-volume loop became rectangular, with well-defined isovolumic phases. The slope of preload recruitable stroke work was increased significantly during pulmonary pressure of 30 mm Hg. The ventricular time constant showed a significant increase with no change of chamber stiffness during pulmonary pressure of 35 mm Hg. Concomitantly, the Tei index increased significantly from 0.06+/-0.03 to 0.31+/-0.06, together with the shortening of the ejection time and a decrease of the E/A ratio (P<0.05). Thus, the right ventricular Tei index was noted to be affected by acute graded afterload increase. The alteration in invasive measurements of systolic and diastolic function makes the Tei index a sensitive indicator of right ventricular dysfunction in the settings of acute pulmonary hypertension.
Juan C Grignola; Fernando Ginés; Daniel Guzzo
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-12-02
Journal Detail:
Title:  International journal of cardiology     Volume:  113     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-11-06     Completed Date:  2007-01-04     Revised Date:  2007-02-22    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  25-33     Citation Subset:  IM    
Departamento de Fisiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
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MeSH Terms
Acute Disease
Blood Pressure
Blood Volume
Cardiac Output
Diagnostic Techniques, Cardiovascular*
Echocardiography, Doppler*
Hypertension, Pulmonary / physiopathology*
Pulmonary Artery / physiopathology
Sensitivity and Specificity
Stroke Volume
Time Factors
Ventricular Function, Right*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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