Document Detail


Comparison of TRH and anorexigenic peptide on food intake and gastrointestinal secretions.
MedLine Citation:
PMID:  6806786     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thyrotropin releasing hormone (TRH), distributed throughout the gastrointestinal tract, and anorexigenic peptide (AP), isolated recently from the urine of females with "hypothalamic" anorexia nervosa, have been shown to affect food intake but no study has been performed to compare their action on gastrointestinal secretions. This report shows that both TRH and AP reduce dose-dependently the food intake during sham-feeding and inhibit gastric and pancreatic secretions in response to various exogenous and endogenous stimulants in conscious dogs. The results indicate that TRH and AP have similar inhibitory action on feeding and gastrointestinal secretory activity and that they may be involved in peptidergic mediation of satiety and gastrointestinal secretion.
Authors:
S J Konturek; J Tasler; J Jaworek; M Dobrzańska; D H Coy; A V Schally
Related Documents :
3956936 - Gastric processing and emptying of fat.
7372066 - Effect of sham feeding on gastric emptying.
24162946 - Effects of food deprivation on the hypothalamic feeding-regulating peptides gene expres...
775976 - 99mtc-tagged chicken liver as a marker of solid food in the human stomach.
24332026 - Salmonella's masterful skill in mast cell suppression.
12564526 - Health survey of wild and captive bog turtles (clemmys muhlenbergii) in north carolina ...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Peptides     Volume:  2 Suppl 2     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  1981  
Date Detail:
Created Date:  1982-08-14     Completed Date:  1982-08-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  235-40     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Anorexia Nervosa / urine
Appetite Depressants
Bicarbonates / blood
Dogs
Dose-Response Relationship, Drug
Eating / drug effects*
Gastric Acid / secretion
Gastric Juice / drug effects,  secretion*
Gastrins / blood
Humans
Insulin / blood
Oligopeptides / pharmacology*
Pancreas / drug effects,  secretion*
Pepsin A / secretion
Proteins / secretion
Thyrotropin-Releasing Hormone / pharmacology*
Chemical
Reg. No./Substance:
0/Appetite Depressants; 0/Bicarbonates; 0/Gastrins; 0/Oligopeptides; 0/Proteins; 11061-68-0/Insulin; 24305-27-9/Thyrotropin-Releasing Hormone; EC 3.4.23.1/Pepsin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Arterial blood-gases and acid-base balance in acute diseases of the lower respiratory tract in infan...
Next Document:  Monoclonal antibodies against a soluble cytoplasmic antigen in human prostatic epithelial cells.