| Comparison of TRH and anorexigenic peptide on food intake and gastrointestinal secretions. | |
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MedLine Citation:
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PMID: 6806786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thyrotropin releasing hormone (TRH), distributed throughout the gastrointestinal tract, and anorexigenic peptide (AP), isolated recently from the urine of females with "hypothalamic" anorexia nervosa, have been shown to affect food intake but no study has been performed to compare their action on gastrointestinal secretions. This report shows that both TRH and AP reduce dose-dependently the food intake during sham-feeding and inhibit gastric and pancreatic secretions in response to various exogenous and endogenous stimulants in conscious dogs. The results indicate that TRH and AP have similar inhibitory action on feeding and gastrointestinal secretory activity and that they may be involved in peptidergic mediation of satiety and gastrointestinal secretion. |
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Authors:
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S J Konturek; J Tasler; J Jaworek; M Dobrzańska; D H Coy; A V Schally |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Peptides Volume: 2 Suppl 2 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 1981 |
Date Detail:
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Created Date: 1982-08-14 Completed Date: 1982-08-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 235-40 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anorexia Nervosa / urine Appetite Depressants Bicarbonates / blood Dogs Dose-Response Relationship, Drug Eating / drug effects* Gastric Acid / secretion Gastric Juice / drug effects, secretion* Gastrins / blood Humans Insulin / blood Oligopeptides / pharmacology* Pancreas / drug effects, secretion* Pepsin A / secretion Proteins / secretion Thyrotropin-Releasing Hormone / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Appetite Depressants; 0/Bicarbonates; 0/Gastrins; 0/Oligopeptides; 0/Proteins; 11061-68-0/Insulin; 24305-27-9/Thyrotropin-Releasing Hormone; EC 3.4.23.1/Pepsin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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