Document Detail

Comparison of TRH and anorexigenic peptide on food intake and gastrointestinal secretions.
MedLine Citation:
PMID:  6806786     Owner:  NLM     Status:  MEDLINE    
Thyrotropin releasing hormone (TRH), distributed throughout the gastrointestinal tract, and anorexigenic peptide (AP), isolated recently from the urine of females with "hypothalamic" anorexia nervosa, have been shown to affect food intake but no study has been performed to compare their action on gastrointestinal secretions. This report shows that both TRH and AP reduce dose-dependently the food intake during sham-feeding and inhibit gastric and pancreatic secretions in response to various exogenous and endogenous stimulants in conscious dogs. The results indicate that TRH and AP have similar inhibitory action on feeding and gastrointestinal secretory activity and that they may be involved in peptidergic mediation of satiety and gastrointestinal secretion.
S J Konturek; J Tasler; J Jaworek; M Dobrzańska; D H Coy; A V Schally
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Peptides     Volume:  2 Suppl 2     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  1981  
Date Detail:
Created Date:  1982-08-14     Completed Date:  1982-08-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  235-40     Citation Subset:  IM    
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MeSH Terms
Anorexia Nervosa / urine
Appetite Depressants
Bicarbonates / blood
Dose-Response Relationship, Drug
Eating / drug effects*
Gastric Acid / secretion
Gastric Juice / drug effects,  secretion*
Gastrins / blood
Insulin / blood
Oligopeptides / pharmacology*
Pancreas / drug effects,  secretion*
Pepsin A / secretion
Proteins / secretion
Thyrotropin-Releasing Hormone / pharmacology*
Reg. No./Substance:
0/Appetite Depressants; 0/Bicarbonates; 0/Gastrins; 0/Oligopeptides; 0/Proteins; 11061-68-0/Insulin; 24305-27-9/Thyrotropin-Releasing Hormone; EC A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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