| Comparison of sufentanil versus fentanyl in ventilated term neonates. | |
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MedLine Citation:
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PMID: 19731193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Increasingly frequent applications of opioid analgesics in neonatal intensive care require the evaluation of efficacy and side effects. PATIENTS: Mechanically ventilated term neonates were consecutively enrolled. METHODS: In a double-blind randomized trial 20 newborns received a continuous intravenous infusion of fentanyl (n=10) or sufentanil (n=10) in an assumed equipotent dose of 7:1. The analgesic dose was individually adjusted according to sedation scores. The period between cessation of analgesic medication and successful extubation (weaning time), adverse drug effects and urinary cortisol concentrations were evaluated. RESULTS: No significant difference of weaning time was seen between fentanyl and sufentanil group (mean weaning time (+/-SD) of fentanyl group 520+/-381 min, median 380 min; sufentanil group 585+/-531 min, median 405 min, p=0.78, 2-tailed U-Test, Mann and Whitney). The mean opioid dose resulted in a 10:1 ratio (fentanyl 4.11 microg/(kg x h) vs sufentanil 0.41 microg/(kg x h)). We found no marked differences in sedation levels, blood pressure, heart rate, oxygenation index, co-medication or urinary cortisol levels. In both groups similar adverse effects were assessed including respiratory depression, mild withdrawal symptoms or decrease of gastrointestinal motility. CONCLUSION: In our study sufentanil did not reduce the weaning period in ventilated term neonates when compared to fentanyl. The equipotent dose ratio for fentanyl/sufentanil was 10:1. According to sedation scores both substances provided effective pain and stress protection. |
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Authors:
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B Schmidt; C Adelmann; H St?tzer; L Welzing; C H?nseler; A Kribs; B Roth |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-09-03 |
Journal Detail:
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Title: Klinische P?diatrie Volume: 222 ISSN: 1439-3824 ISO Abbreviation: Klin Padiatr Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-22 Completed Date: 2010-06-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0326144 Medline TA: Klin Padiatr Country: Germany |
Other Details:
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Languages: eng Pagination: 62-6 Citation Subset: IM |
Copyright Information:
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(c) Georg Thieme Verlag KG Stuttgart-New York. |
Affiliation:
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Department of Neonatology and Pediatric Intensive Care Medicine, Children's Hospital, University of Cologne. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, Intravenous* Anesthetics, Intravenous* / pharmacokinetics Arousal / drug effects Dose-Response Relationship, Drug Double-Blind Method Fentanyl* / pharmacokinetics Half-Life Humans Infant, Newborn Intermittent Positive-Pressure Breathing Intermittent Positive-Pressure Ventilation* Oxygen Inhalation Therapy Pain Measurement / drug effects Positive-Pressure Respiration Prospective Studies Respiratory Distress Syndrome, Newborn / therapy* Sufentanil* / pharmacokinetics Ventilator Weaning |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Intravenous; 437-38-7/Fentanyl; 56030-54-7/Sufentanil |
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