Document Detail

Comparison of SPECT findings and neuropsychological sequelae in carbon monoxide and organophosphate poisoning.
MedLine Citation:
PMID:  18344103     Owner:  NLM     Status:  MEDLINE    
Abnormal regional cerebral blood flow in patients with acute carbon monoxide (CO) and organophosphate (OP) poisoning was examined using (99m)Tc-hexamethylpropylene amine oxime (HMPAO) brain single photon emission computed tomography (SPECT) in fourteen patients. We evaluated the predictive significance of acute phase brain SPECT findings for long-term neuropsychological sequelae. Changes were found in the frontal, temporal, parietal lobes within the first week after both types of poisoning. The distribution of the hypoperfused cerebral areas as demonstrated by (99m)Tc-HMPAO imaging was similar in the two groups during the acute phase. Neuropsychological sequelae developed in five patients poisoned with OP and six with CO. Patients who had SPECT findings heterogeneously or in the temporal or frontal lobes displayed disorientation. Those with fronto-parietal and frontal lobe changes displayed mental confusion. Parkinsonism also was observed in patients with parieto-occipital, parietal and frontal lobe lesions. The distribution of these lesions appears to predict the long term sequelae of these poisonings, though additional studies with larger numbers of patients are needed to confirm the role of SPECT imaging in both OP and CO poisonings.
Gurayten Ozyurt; Fatma Nur Kaya; Ferda Kahveci; Eray Alper
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical toxicology (Philadelphia, Pa.)     Volume:  46     ISSN:  1556-3650     ISO Abbreviation:  Clin Toxicol (Phila)     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-05-06     Revised Date:  2009-11-17    
Medline Journal Info:
Nlm Unique ID:  101241654     Medline TA:  Clin Toxicol (Phila)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  218-21     Citation Subset:  AIM; IM    
Uludag University, Bursa, Turkey.
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MeSH Terms
Brain / radionuclide imaging
Carbon Monoxide Poisoning / psychology*,  radionuclide imaging*
Carboxyhemoglobin / metabolism
Neuropsychological Tests
Phosphoric Acid Esters / poisoning*
Poisoning / psychology*,  radionuclide imaging*
Radiopharmaceuticals / diagnostic use
Technetium Tc 99m Exametazime / diagnostic use
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
0/Phosphoric Acid Esters; 0/Radiopharmaceuticals; 100504-35-6/Technetium Tc 99m Exametazime; 9061-29-4/Carboxyhemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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