Document Detail

Comparison of respiratory parameters and plasma cytokine levels between treatment with Salmeterol/fluticasone and ipratropium/terbutaline/budesonide in mechanically ventilated COPD patients.
MedLine Citation:
PMID:  23127342     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It is unknown whether the bronchodilation and anti-inflammatory effects of inhaled salmeterol and fluticasone (SF) are better than those of traditionally inhaled ipratropium, terbutaline and budesonide (ITB) in mechanically ventilated patients with chronic obstructive pulmonary disease (COPD).
METHODS: Nineteen stable COPD patients with respiratory failure were randomly enrolled into two groups. Patients were treated with inhaled SF delivered by a metered-dose inhaler with a spacer or with inhaled nebulized ITB. Respiratory parameters were measured for 7 days and plasma cytokine levels were measured on days 1 and 7.
RESULTS: The kinetic curve of the rapid shallow index (RSI) from day 1 to day 7 was significant lower in the SF group than that in the ITB group. There were no significant differences in minute ventilation, intrinsic positive end expiratory pressure, and airway resistance between the ITB and SF groups from day 1 to day 7. There were no differences in plasma interleukin (IL)-6, IL-10, IL- 12, and transforming growth factor-beta1 levels between day 1 and day 7 in the ITB or SF group.
CONCLUSIONS: Patients with inhaled SF treatment had a lower RSI. The effects of bronchodilators and anti-inflammation were similar between inhaled SF and ITB in COPD patients with ventilator support.
Huang-Pin Wu; Yu-Chih Liu; Shi-Chuan Lin; Ming-Yi Chien; Fang-Chun Liao; Shu-Chuan Chang; Wen-Bin Shieh
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chang Gung medical journal     Volume:  35     ISSN:  2309-835X     ISO Abbreviation:  Chang Gung Med J     Publication Date:    2012 Sep-Oct
Date Detail:
Created Date:  2012-11-06     Completed Date:  2013-11-13     Revised Date:  2013-12-29    
Medline Journal Info:
Nlm Unique ID:  101088034     Medline TA:  Chang Gung Med J     Country:  China (Republic : 1949- )    
Other Details:
Languages:  eng     Pagination:  373-81     Citation Subset:  IM    
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MeSH Terms
Administration, Inhalation
Adrenergic beta-2 Receptor Agonists / administration & dosage*
Aged, 80 and over
Albuterol / administration & dosage,  analogs & derivatives*
Bronchodilator Agents / administration & dosage*
Budesonide / administration & dosage*
Cytokines / blood
Drug Therapy, Combination
Ipratropium / administration & dosage*
Middle Aged
Pulmonary Disease, Chronic Obstructive / drug therapy*
Respiratory Function Tests
Terbutaline / administration & dosage*
Reg. No./Substance:
0/Adrenergic beta-2 Receptor Agonists; 0/Bronchodilator Agents; 0/Cytokines; 2I4BC502BT/salmeterol; 51333-22-3/Budesonide; GR88G0I6UL/Ipratropium; N8ONU3L3PG/Terbutaline; QF8SVZ843E/Albuterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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