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Comparison of Preserved Vascular Allografts Using Glycerol and University of Wisconsin Solution in a Goat Carotid Artery Transplantation Model.
MedLine Citation:
PMID:  22212135     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Prosthetic grafts have poor patency rates in peripheral arterial reconstructions. Glycerol (GL)-preserved grafts are an alternative. The aim of this study was to examine patency, graft morphology and function of GL-preserved allografts in a goat carotid artery animal model. Methods: The first group (n = 7) underwent bilateral replacement of the carotid artery by a carotid allograft that was preserved in GL for 1 week. In the second group (n = 5), a carotid artery allograft that was preserved in University of Wisconsin solution (UW) for 48 h was used. In the third group (n = 5), the jugular vein (autologous vein, AU) was used. The follow-up was 3 months. Results: One UW graft and 1 GL graft occluded in the first 24 h postoperatively. Three-month primary patency rates for GL, UW and AU grafts were 93, 100 and 80%, respectively (p = 0.39). Graft diameter was increased in UW allografts (p < 0.005), whereas GL allografts remained unchanged. After explantation, GL allografts demonstrated contraction and relaxation capacity and lower intimal thickness (p < 0.001). Conclusion: GL preservation has proven to be a feasible method for arterial allograft transplantation in a large animal model with decreased intimal hyperplasia and renewed functional capability.
Authors:
P J Fahner; D A Legemate; A C van der Wal; J van Marle; S L M Peters; C F van Eck; T M van Gulik; M M Idu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-30
Journal Detail:
Title:  European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes     Volume:  48     ISSN:  1421-9921     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0174752     Medline TA:  Eur Surg Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  64-72     Citation Subset:  -    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Affiliation:
Department of Surgery and Surgical Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
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