Document Detail

Comparison of the predictability of neurological outcome by serum procalcitonin and glial fibrillary acidic protein in postcardiac-arrest patients.
MedLine Citation:
PMID:  20033352     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In past research, procalcitonin (PCT) and glial fibrillary acidic protein (GFAP) have been reported to be useful biomarkers in predicting neurological outcome after the return of spontaneous circulation (ROSC) following out-of-hospital cardiac arrest (CA), although they have only been studied separately. In this study, we compared the usefulness of PCT and GFAP in predicting neurological outcome. METHODS: This study was a retrospective, single-center analysis, conducted in the intensive-care unit of a university hospital. Twenty-one sequential post-CA patients were included. Serum samples were collected from patients at 12 and 24 h after ROSC. Serum PCT and GFAP were measured and compared in patients with favorable and unfavorable neurological outcomes, evaluated at 6 months using the Glasgow-Pittsburgh Cerebral Performance Categories. RESULTS: Serum PCT was significantly higher at 12 and 24 h in patients with unfavorable outcomes (P = 0.004 and 0.002, respectively). Serum GFAP was not significantly higher at 12 and 24 h in patients with unfavorable outcomes (P = 0.118 and 0.079, respectively). The combination of PCT and GFAP showed high predictive value for unfavorable outcomes (86.7% sensitivity and 100% specificity at 12 h; 100% sensitivity and 83.3% specificity at 24 h). CONCLUSION: Serum PCT is a marker of unfavorable neurological outcome in post-CA patients, and is superior to serum GFAP in the early phase.
Hiromi Hayashida; Tadashi Kaneko; Shunji Kasaoka; Chiyomi Oshima; Takashi Miyauchi; Motoki Fujita; Yasutaka Oda; Ryosuke Tsuruta; Tsuyoshi Maekawa
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurocritical care     Volume:  12     ISSN:  1556-0961     ISO Abbreviation:  Neurocrit Care     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-23     Completed Date:  2010-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101156086     Medline TA:  Neurocrit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  252-7     Citation Subset:  IM    
Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, 1-1-1 Minamikogushi, Ube, Yamaguchi, Japan.
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MeSH Terms
Brain / blood supply*,  physiopathology*
Calcitonin / blood*
Cardiopulmonary Resuscitation
Cerebrovascular Circulation / physiology
Glial Fibrillary Acidic Protein / blood*
Heart Arrest / blood*,  mortality*
Middle Aged
Predictive Value of Tests
Protein Precursors / blood*
Retrospective Studies
Survival Rate
Treatment Outcome
Reg. No./Substance:
0/Glial Fibrillary Acidic Protein; 0/Protein Precursors; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin

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