Document Detail

Comparison of penile size and erectile function after high-intensity focused ultrasound and targeted cryoablation for localized prostate cancer: a prospective pilot study.
MedLine Citation:
PMID:  20233294     Owner:  NLM     Status:  In-Process    
INTRODUCTION: Erectile dysfunction (ED) represents a common quality-of-life issue of any treatment used for prostate cancer, including high-intensity focused ultrasound (HIFU) and targeted cryoablation of the prostate (TCAP). There is a paucity of comparative studies regarding the difference in the erectile function and penile size of patients undergoing HIFU or TCAP.
AIM: The aim of this study is to compare the erectile function and penile size of patients undergoing HIFU or TCAP.
METHODS: Patients with a preoperative erectile function domain of the International Index of Erectile Function (IIEF-EF) score ≥ 26 were prospectively included. All patients were preoperatively evaluated by IIEF-EF and penile color Doppler ultrasound. Penile length and circumference were measured in flaccidity and at maximum erection. At 6, 12, 18, 24, 36 months after surgery, patients were assessed with the same protocol.
MAIN OUTCOME MEASURES: IIEF-EF score, penile color Doppler ultrasound, penile length, and circumference at different time points.
RESULTS: There were 55 patients in the HIFU group and 47 in the TCAP group. At each time point, there were significant differences in mean IIEF-EF scores and penile color Doppler results between the two groups. At 36 months, TCAP patients experienced lower erectile function recovery rate compared with HIFU patients (TCAP=46.8%; HIFU=65.5%; P=0.021). No significant decreases in penile length and circumference were found in the two groups (all P values ≥ 0.05).
CONCLUSIONS: Our data demonstrate TCAP caused significantly decreased erectile function than HIFU. We found no change in penile size after HIFU or TCAP. The option of HIFU may be more attractive to the patient who wants to avoid ED afterward, to maintain their quality of life.
Liao-Yuan Li; Zhe Lin; Ming Yang; Xin Gao; Tao-Lin Xia; Tao Ding
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of sexual medicine     Volume:  7     ISSN:  1743-6109     ISO Abbreviation:  J Sex Med     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-11-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230693     Medline TA:  J Sex Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3135-42     Citation Subset:  IM    
Copyright Information:
© 2010 International Society for Sexual Medicine.
The Third Affiliated Hospital, Sun Yat-Sen University, Department of Urology, Guangzhou, China.
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