Document Detail

Comparison of PY 108-068, a new calcium antagonist, with nifedipine in exercise-induced asthma.
MedLine Citation:
PMID:  3525023     Owner:  NLM     Status:  MEDLINE    
Several calcium antagonists, each with significantly different chemical structures, have demonstrated variable attenuation of exercise-induced asthma. Quantitative comparisons have been hampered by differences in the intensity of challenge and the severity of the underlying disease between groups of patients. In 12 asthmatic adults with relatively severe exercise-induced asthma, we compared the effect of a new calcium antagonist, PY 108-068, in doses of 75 mg and 150 mg with nifedipine (30 mg) and placebo on resting flow rates and flow rates after exercise. Over a three-week period, each patient completed a four-day, randomized, double-blind Latin-square study. After receiving one of four oral drugs, spirometry was repeated every 30 minutes for two hours, followed by a six-minute treadmill exercise test breathing dry air. The exercise tests were well matched for work rate, ventilation, heart rate, and oxygen uptake. Spirometry was then repeated seven times over the next 30 minutes after exercise. Though both 150 mg of PY 108-068 and nifedipine were associated with mild bronchodilation before exercise, only the latter was significant (p less than 0.05). Exercise-induced asthma (expressed as maximal percent fall in the forced expiratory volume in one second from before baseline) was significantly attenuated only by 150 mg of PY 108-068 compared to placebo (24 +/- 13 vs 40 +/- 16; p less than 0.05). Headache, which occurred in six subjects after nifedipine, five after 150 mg of PY 108-068, one after 75 mg of PY 108-068, and none after placebo, was subjectively more severe after nifedipine. We conclude that in these patients, there was a tendency for mild bronchodilation before exercise with both 150 mg of PY 108-068 and nifedipine, but only the 150-mg dose provided significant protection against exercise-induced asthma two hours after the drug.
S R Olive; J E Hansen; D Y Sue; I Ben-Dov; K Wasserman
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Chest     Volume:  90     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  208-11     Citation Subset:  AIM; IM    
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MeSH Terms
Asthma / drug therapy*
Asthma, Exercise-Induced / drug therapy*
Bronchi / drug effects
Calcium Channel Blockers / therapeutic use*
Clinical Trials as Topic
Double-Blind Method
Exercise Test
Heart Rate / drug effects
Middle Aged
Nifedipine / analogs & derivatives*,  therapeutic use*
Pulmonary Ventilation / drug effects
Random Allocation
Time Factors
Reg. No./Substance:
0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 72803-02-2/darodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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