Document Detail


Comparison of 1-year vs 2-year change in regional cartilage thickness in osteoarthritis results from 346 participants from the Osteoarthritis Initiative.
MedLine Citation:
PMID:  21044690     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare femorotibial cartilage thickness changes over a 2- vs a 1-year observation period in knees with radiographic knee osteoarthritis (OA).
METHODS: One knee of 346 Osteoarthritis Initiative (OAI) participants was studied at three time points [baseline (BL), year-1 (Y1), year-2 (Y2) follow-up]: 239 using coronal fast low angle shot (FLASH) and 107 using sagittal double echo at steady state (DESS) MR imaging. Changes in cartilage thickness were assessed in femorotibial cartilage plates and subregions, after manual segmentation with blinding to time-point.
RESULTS: The standardized response mean (SRM) of total joint cartilage thickness over 2 years was modestly higher than over 1 year (FLASH: -0.44 vs -0.32/-0.28 [first/second year]; DESS: -0.42 vs -0.39/-0.18). For the subregion showing the largest change per knee (OV1), the 2-year SRM was similar or lower (FLASH: -1.20 vs -1.22/-1.61; DESS: -1.38 vs -1.64/-1.51) than the 1-year SRM. The changes in total joint cartilage thickness were not significantly different in the first and second year (FLASH: -0.8% vs -0.7%; DESS: -1.3% vs -0.8%) and were negatively correlated. Analysis of smallest detectable changes (SDCs) revealed that only few participants displayed significant progression in both consecutive periods. The location of the subregion contributing to OV1 in each knee was highly inconsistent between the first and second year observation period.
CONCLUSIONS: The SRM of region-based cartilage thickness change in OA is modestly larger following a 2-year vs a 1-year observation period, while it is relatively similar when an OV-approach is chosen. Structural progression displays strong temporal and spatial heterogeneity at an individual knee level that should be considered when planning clinical trials.
Authors:
W Wirth; S Larroque; R Y Davies; M Nevitt; A Gimona; F Baribaud; J H Lee; O Benichou; B T Wyman; M Hudelmaier; S Maschek; F Eckstein;
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-10-31
Journal Detail:
Title:  Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society     Volume:  19     ISSN:  1522-9653     ISO Abbreviation:  Osteoarthr. Cartil.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-27     Completed Date:  2011-02-24     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9305697     Medline TA:  Osteoarthritis Cartilage     Country:  England    
Other Details:
Languages:  eng     Pagination:  74-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Osteoarthritis Research Society International. All rights reserved.
Affiliation:
Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria. wolfgang.wirth@pmu.ac.at
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MeSH Terms
Descriptor/Qualifier:
Aged
Cartilage, Articular / pathology*
Cohort Studies
Disease Progression
Female
Femur / pathology
Humans
Knee Joint / pathology
Magnetic Resonance Imaging
Male
Middle Aged
Osteoarthritis, Knee / pathology*
Tibia / pathology
Time Factors
Grant Support
ID/Acronym/Agency:
N01 AR022258/AR/NIAMS NIH HHS; N01-AR-2-2258/AR/NIAMS NIH HHS; N01-AR-2-2259/AR/NIAMS NIH HHS; N01-AR-2-2260/AR/NIAMS NIH HHS; N01-AR-2-2261/AR/NIAMS NIH HHS; N01-AR-2-2262/AR/NIAMS NIH HHS
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