Document Detail


Comparison of Neurotropic Effects of L-Glutamic Acid and Its New Derivative β-Phenylglutamic Acid Hydrochloride (RGPU-135, Glutarone).
MedLine Citation:
PMID:  24824696     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
In contrast to L-glutamic acid (200 mg/kg), β-phenylglutamic acid hydrochloride (26 mg/kg) produces no anticonvulsant effects during generalized convulsions induced by "maximum electric shock". However, β-phenylglutamic acid hydrochloride was more potent than L-glutamic acid in increasing survival rate, promoting recovery of spontaneous motor activity, and maintainance locomotor and exploratory activity in the open fi eld test and cognitive functions in conditioned passive avoidance test, i.e. exhibited neuroprotective activity. This substance did not change the threshold of pain induced by electric stimulation of paws (up to vocalization) and thermal tail stimulation (tail-fl ick), whereas L-glutamic acid decreased this parameter. β-Phenylglutamic acid suppressed aggression in the test for provoked unmotivated aggression, while L-glutamic acid enhanced it. Due to these neurotropic effects, β-phenylglutamic acid hydrochloride can be used as the basis for the development of drugs with antidepressant, anxiolytic, and neuroprotective actions.
Authors:
I N Tyurenkov; V V Bagmetova; Yu V Chernysheva; O V Merkushenkova
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Publication Detail:
Type:  Journal Article     Date:  2014-05-03
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  156     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-05-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  781-4     Citation Subset:  IM    
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