Document Detail

Comparison of near-infrared and short-wavelength autofluorescence in retinitis pigmentosa.
MedLine Citation:
PMID:  23287793     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare near-infrared autofluorescence (NIR-AF) and short-wavelength (SW) AF in retinitis pigmentosa (RP) and assess their relationships to underlying retinal structure and visual function.
METHODS: SW-AF, NIR-AF, and spectral domain optical coherence tomography (SD-OCT) images were acquired from 31 patients (31 eyes) with RP and registered to each other. Microperimetry was performed on a subset of 12 patients. For both SW-AF and NIR-AF images, three independent observers measured the area enclosed by the outer border of the hyperautofluorescent ring and the distance from the fovea to the outer and inner border of the ring. For SD-OCT images, the distance from the fovea to the location where the inner segment ellipsoid (ISe) band became undetectable was measured.
RESULTS: All eyes had a hyperautofluorescent ring on both SW-AF and NIR-AF. The position of the outer border of the ring was similar for both modalities. On NIR-AF the signal outside the ring was lower than inside the ring, resulting in a high contrast between the two areas. Also, the inner border of the ring was closer to the fovea on NIR-AF than SW-AF, corresponding to a location on SD-OCT where the ISe band was at least partially intact. Visual sensitivity was relatively preserved within the ring, reduced across the ring, and markedly decreased or nonrecordable outside the ring.
CONCLUSIONS: SW-AF and NIR-AF are both useful for monitoring disease progression in RP; however, NIR-AF may have advantages clinically and could unveil a process that precedes the formation of fluorophores that emit the SW-AF signal.
Tobias Duncker; Mirela R Tabacaru; Winston Lee; Stephen H Tsang; Janet R Sparrow; Vivienne C Greenstein
Related Documents :
4046053 - The computed tomographic spectrum of cerebral cysticercosis.
24454963 - Sequence comparison for non-enhanced mra of the lower extremity arteries at 7 tesla.
1410033 - Continuous versus intraoperative expansion in the pig model.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-17
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  54     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-18     Completed Date:  2013-03-19     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  585-91     Citation Subset:  IM    
Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University, New York, New York 10032, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cross-Sectional Studies
Fluorescein Angiography / methods*
Fovea Centralis / pathology*
Fundus Oculi
Middle Aged
Retinitis Pigmentosa / pathology,  physiopathology*
Tomography, Optical Coherence / methods
Visual Field Tests
Visual Fields / physiology*
Young Adult
Grant Support
P30 EY019007/EY/NEI NIH HHS; R01 EY009076/EY/NEI NIH HHS; R01 EY09076/EY/NEI NIH HHS; R24 EY019861/EY/NEI NIH HHS; R24 EY019861/EY/NEI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Basal blood flow and autoregulation changes in the optic nerve of rhesus monkeys with idiopathic bil...
Next Document:  sCD44 internalization in human trabecular meshwork cells.