| Comparison of a Multidose Powder Inhaler Containing Beclomethasone Dipropionate (BDP) with a BDP Metered Dose Inhaler with Spacer in the Treatment of Asthmatic Patients. | |
| | |
MedLine Citation:
|
PMID: 18370527 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: The clinical efficacy, tolerability and acceptability of a new multidose powder inhaler (MDPI) [Easyhaler((R)), Orion Pharma, Finland] containing a high dose (500 microg/dose) of beclomethasone dipropionate (BDP) were compared with those of BDP metered dose inhaler administered with a large volume spacer (MDI-spacer). PATIENTS AND STUDY DESIGN: Recruited patients were adult asthmatics currently receiving 800 to 1000 microg/day of inhaled corticosteroid. The dose of BDP during the study was 1000 mg/day. The study was an open, randomised, parallel-group multicentre study and included a 2-week run-in period followed by a 12-week treatment period. RESULTS: 74 patients were randomised to both groups. During the run-in period the mean morning peak expiratory flow (PEF) was 489 and 478 L/min in the MDPI and MDI-spacer groups, respectively. During the last 2 weeks of the study the morning PEF was 485 L/min in the MDPI group and 477 L/min in the MDI-spacer group. Asthma symptom scores and use of rescue medication were low in both groups. The median dose of histamine required to decrease forced expiratory volume in 1 second (FEV(1)) by 15% was 1.05mg in the MDPI group and 0.64mg in the MDI-spacer group. The most frequent adverse events were hoarseness and sore throat. Mean serum cortisol levels were not affected in either treatment group. Patients' personal opinion regarding acceptability of the devices clearly favoured the MDPI. CONCLUSION: In conclusion, the novel powder inhaler was well tolerated and at least equally effective compared with the conventional MDI-spacer combination in the treatment of asthma with BDP. However, in everyday use the patients clearly favoured the powder inhaler. |
| | |
Authors:
|
A Poukkula; K Alanko; K Kilpiö; A Knuuttila; S Koskinen; J Laitinen; K Lehtonen; K Liippo; A Lindqvist; S Lähelmä; M Paananen; E M Ruotsalainen; E R Salomaa; M Silvasti; U Suuronen; P Toivanen; V Vilkka |
Related Documents
:
|
7809497 - Inhaled budesonide for maintenance treatment of pulmonary sarcoidosis. 15726607 - Treatment, outcome, and cost of care in children with idiopathic thrombocytopenic purpura. 14646387 - Safety of subcutaneous specific immunotherapy with pollen allergen extracts for respira... 9481097 - Treatment of diffuse proliferative lupus nephritis: an indian experience. 7477807 - Vitamin supplementation for 1 year improves mood. 22713087 - A randomized controlled trial of sodium phosphate tablets and polyethylene glycol solut... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical drug investigation Volume: 16 ISSN: 1173-2563 ISO Abbreviation: Clin Drug Investig Publication Date: 1998 |
Date Detail:
|
Created Date: 2008-03-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9504817 Medline TA: Clin Drug Investig Country: New Zealand |
Other Details:
|
Languages: eng Pagination: 101-10 Citation Subset: - |
Affiliation:
|
Oulu University Hospital, Oulu, Finland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Impact of a New Formulation of Low-Dose Micronised Medroxyprogesterone and 17-beta Estradiol on Lipi...
Next Document: Assessment of HPA-Axis Suppression with Fluticasone Cream 0.05% in Patients with Extensive Psoriasis...