| A comparison of magnesium sulphate and sildenafil in the treatment of the newborns with persistent pulmonary hypertension: a randomized controlled trial. | |
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MedLine Citation:
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PMID: 20923790 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The aim of this prospective, randomized and controlled study was to compare the clinical efficacy of intravenous magnesium sulfate (MgSO(4)) and oral sildenafil therapies with persistent pulmonary hypertension of the newborn. A total of 34 infants in the MgSO(4) group and 31 infants in the sildenafil group completed the study. The time to reach the adequate clinical response [defined as oxygen index (OI) level of <15, a pulmonary artery pressure of <20 mmHg) was significantly shorter in the sildenafil group ( p = 0.002). Duration of mechanical ventilation was longer and the number of the patients requiring inotropic support was higher in the MgSO(4) group ( p = 0.001 and p = 0.002, respectively). Although among two groups the difference in OI > 5 as speculated in our hypothesis could only be found at 36 h of the treatment, sildenafil was more effective than MgSO(4) in the treatment of persistent pulmonary hypertension of the newborns with regard to time to adequate clinical response, duration of mechanical ventilation and support requirement with inotropic agents. |
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Authors:
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Sinan Uslu; Soner Kumtepe; Ali Bulbul; Serdar Comert; Fatih Bolat; Asiye Nuhoglu |
Publication Detail:
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Type: Journal Article Date: 2010-10-04 |
Journal Detail:
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Title: Journal of tropical pediatrics Volume: 57 ISSN: 1465-3664 ISO Abbreviation: J. Trop. Pediatr. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8010948 Medline TA: J Trop Pediatr Country: England |
Other Details:
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Languages: eng Pagination: 245-50 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Division of Neonatology, Sisli Children Hospital, Istanbul, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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