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Comparison of Late Potentials for 24 Hours between Brugada Syndrome and Arrhythmogenic Right Ventricular Cardiomyopathy Using a Novel Signal-Averaging System Based on Holter Electrocardiogram.
MedLine Citation:
PMID:  22665699     Owner:  NLM     Status:  Publisher    
BACKGROUND: -Late potentials (LP) detected with signal-averaged electrocardiograms (SAECGs) are known as being useful for identifying patients at risk of Brugada syndrome (BS) and arrhythmogenic right ventricular cardiomyopathy (ARVC). As the pathophysiology is clearly different between these disorders, we clarified the LP characteristics of these disorders. METHODS AND RESULTS: -This study included 15 BS and 12 ARVC patients and 20 healthy controls. All BS patients had characteristic electrocardiogram changes and symptomatic episodes. All ARVC patients had findings that were consistent with recent criteria. Three LP parameters (fQRS, RMS(40), and LAS(40)) were continuously measured for 24 hours using a novel Holter-based SAECG system. The incidences of LP determination in BS (80%) and ARVC patients (91%) were higher than in healthy controls (5%; P<0.0001 in both), but did not differ between BS and ARVC patients. In BS patients, dynamic changes of all LP parameters were observed and they were pronounced at nighttime. On the contrary, these findings were not observed in ARVC patients. When values of the standard deviation of three LP parameters (fQRS, RMS(40), LAS(40)) over 24 hours were compared for the two patient groups, those values in BS patients were significantly greater than those in ARVC patients (P<0.0001 in all). CONCLUSIONS: -LP characteristics detected by the Holter-based SAECG system over 24 hours differ between BS and ARVC patients. Dynamic daily variations of LPs were only seen in BS patients. This may imply that mechanisms of lethal ventricular arrhythmia in BS may be more correlated with autonomic abnormality than that of ARVC.
Atsuko Abe; Kenzaburo Kobayashi; Hitomi Yuzawa; Hideyuki Sato; Shunji Fukunaga; Tadashi Fujino; Yoshifumi Okano; Junichi Yamazaki; Yosuke Miwa; Hideaki Yoshino; Takanori Ikeda
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-4
Journal Detail:
Title:  Circulation. Arrhythmia and electrophysiology     Volume:  -     ISSN:  1941-3084     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101474365     Medline TA:  Circ Arrhythm Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 Toho University Faculty of Medicine, Tokyo, Japan;
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