Document Detail


Comparison of KRN2391 with nicorandil and nifedipine on canine coronary blood flow: antagonism by glibenclamide.
MedLine Citation:
PMID:  1383619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mode of action of KRN2391 [N-cyano-N'-(2-nitroxyethyl)-3- pyridinecarboximidamide monomethanesulfonate] in coronary circulation was examined in anesthetized dogs in comparison with those of nicorandil and nifedipine. Administration of KRN2391 (10 micrograms/kg i.v.), nicorandil (300 micrograms/kg i.v.), and nifedipine (3 micrograms/kg i.v.) caused an increase in coronary blood flow (CBF) and decreases in mean blood pressure (MBP) and in coronary vascular resistance (CVR). Heart rate (HR) was slightly and simultaneously increased by the drugs. Glibenclamide (5 mg/kg i.v.) blocked the changes of these parameters caused by KRN2391 and nicorandil, but not those caused by nifedipine. The present study suggests that the mechanism of action through ATP-sensitive K channels which are blocked by glibenclamide may contribute, at least in part, to the effects of KRN2391 and nicorandil on CBF and blood pressure (BP).
Authors:
N Ogawa; Y Fukata; S Kaneta; Y Jinno; H Fukushima; K Nishikori
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  20     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-11-04     Completed Date:  1992-11-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  11-7     Citation Subset:  IM    
Affiliation:
Pharmaceutical Research Laboratory of Kirin Brewery, Gunma, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antihypertensive Agents / pharmacology
Blood Pressure / drug effects
Coronary Circulation / drug effects*
Dogs
Dose-Response Relationship, Drug
Female
Glyburide / pharmacology*
Heart Rate / drug effects
Male
Niacinamide / analogs & derivatives*,  antagonists & inhibitors,  pharmacology
Nicorandil
Nifedipine / antagonists & inhibitors,  pharmacology*
Potassium Channels / drug effects
Pyridines / antagonists & inhibitors,  pharmacology*
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Potassium Channels; 0/Pyridines; 10238-21-8/Glyburide; 134431-49-5/N-cyano-N'-(2-nitroxyethyl)-3-pyridinecarboximidamide methanesulfonate; 21829-25-4/Nifedipine; 65141-46-0/Nicorandil; 98-92-0/Niacinamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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