Document Detail

Comparison of iris insertion classification among american caucasian and ethnic Chinese using ultrasound biomicroscopy.
MedLine Citation:
PMID:  23633662     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To qualitatively classify and compare types of iris insertion among American Caucasians, American Chinese, and mainland Chinese.
METHODS: Prospective multicenter cross-sectional study. Sex- and age-matched Caucasian, American Chinese, and mainland Chinese cohorts were enrolled. Ultrasound biomicroscopy (UBM) images of the anterior chamber were acquired. Qualitative classification of iris insertion into basal, middle, and apical categories was performed. Proportions of each type of insertion were compared among racial groups. Multivariate logistic regression was carried out adjusting for potential confounders.
RESULTS: data from 117, 129, and 112 subjects were available for american caucasian, american chinese, and mainland chinese subjects, respectively. The most common type of iris insertion in the superior quadrant was basal insertion in both ethnic Chinese and Caucasians. In the inferior, nasal, and temporal quadrants, chinese showed significantly higher proportions of nonbasal insertion (P = 0.048, P 0.0001, P 0.0001, respectively). After adjusting for confounders, nonbasal insertion was significantly associated with Chinese ethnicity in nasal and temporal quadrants (nasal, OR: 3.1, temporal, OR: 4.8). Increasing proportions of nonbasal insertion were found with advancing age in both Chinese and Caucasians.
CONCLUSIONS: Chinese have significantly higher proportions of nonbasal iris insertion in the nasal and temporal quadrants when compared with Caucasians, even after adjusting for ASOCT-measured anterior segment biometry and iris characteristics. Longitudinal studies in patients who have PAC/PACG are needed to fully elucidate the relationship between iris insertion and angle closure development.
Ye Elaine Wang; Yingjie Li; Dandan Wang; Mingguang He; Lingling Wu; Shan C Lin
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-06-03
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  54     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-04     Completed Date:  2013-07-29     Revised Date:  2013-12-03    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3837-43     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Analysis of Variance
Asian Americans
Asian Continental Ancestry Group*
China / ethnology
Cross-Sectional Studies
European Continental Ancestry Group*
Glaucoma, Angle-Closure / ethnology,  ultrasonography*
Iris / anatomy & histology,  ultrasonography*
Logistic Models
Microscopy, Acoustic
Middle Aged
Prospective Studies
United States
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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