Document Detail

Comparison of Intraocular Pressure-Lowering Effect of Every Night Versus Every Other Night Dosing of Bimatoprost 0.03%
MedLine Citation:
PMID:  21663517     Owner:  NLM     Status:  Publisher    
Abstract Purpose: To compare intraocular pressure (IOP) reduction profiles of bimatoprost 0.03% administered every other night (QOD-HS) compared with every night (QHS) in patients with primary open angle glaucoma and pseudoexfoliation glaucoma. Methods: A retrospective chart review of 68 eyes of 45 consecutive patients who were switched from QHS to QOD-HS bimatoprost due to intolerable conjunctival hyperemia between May 2005 and May 2008. IOP in the morning (AM) and afternoon (PM) of the next day after administration (day 1) and the day after (day 2) on QOD-HS regimen was compared with IOP in the AM and PM when they were on QHS regimen, 4-6 weeks after switching to QOD-HS. Results: Mean IOPs on QHS bimatoprost were 15.9±3.4 mm Hg in the AM and 15.5±2.7 mm Hg in the PM, whereas mean IOPs on QOD-HS were 14±2 mm Hg (AM) and 14.2±2.5 mm Hg (PM) on day 1, and 14.7±2.6 mm Hg (AM) and 14.4±2.4 mm Hg (PM) on day 2 after administration. Differences between IOP fluctuation on QHS and QOD-HS days 1 and 2, respectively, were not significant (P=0.87 and 0.94). Conclusion: Every other night dosing of bimatoprost was effective in controlling IOP in this select group of patients with primary open angle glaucoma and pseudoexfoliation glaucoma who had troublesome side effects on bimatoprost 0.03% QHS regimen, and may be considered as an alternative to every day treatment.
Tarek A Shazly; Mark A Latina
Related Documents :
21881597 - Low-dose atorvastatin reduces ambulatory blood pressure in patients with mild hypertens...
21675827 - Trends in blood pressure control in patients with type 2 diabetes - data from the swedi...
25114277 - Commentary on the 2014 bp guidelines from the panel appointed to the eighth joint natio...
12760977 - Acute intravascular volume expansion with rapidly administered crystalloid or colloid i...
16287427 - What role do adrenoreceptor polymorphisms play in modifying cardiovascular responses in...
15450107 - Pressure-independent cardiac effects of angiotensin ii in pigs.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-11
Journal Detail:
Title:  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics     Volume:  -     ISSN:  1557-7732     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9511091     Medline TA:  J Ocul Pharmacol Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 Department of Ophthalmology, Massachusetts Eye and Ear Infirmary/Harvard Medical School , Boston, Massachusetts.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Tryptophan Supplements Promote Pregnancy Success in Mice Challenged with Pseudorabies Virus (PRV) by...
Next Document:  Effects of Passiflora edulis on the Metabolic Profile of Diabetic Wistar Rat Offspring.