| Comparison of immunotoxic effects induced by the extracts from methanol and gasoline engine exhausts in vitro. | |
| | |
MedLine Citation:
|
PMID: 20307646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Gasoline engine exhaust has been considered as a major source of air pollution in China. Due to lower cyto- and geno-toxicity effects of methanol engine exhaust, methanol is regarded as a potential substitute for gasoline. We have previously compared cyto- and geno-toxicities of gasoline engine exhaust with that of methanol engine exhaust in A549 cells (Zhang et al., 2007).To characterize the immunotoxic effects for gasoline and methanol engine exhausts in immune cell, in this study, we further compared effects of gasoline and methanol engine exhausts on immune function in RAW264.7 cell and rabbit alveolar macrophages. Results showed that both gasoline and methanol engine exhaust could evidently inhibit RAW264.7 cell proliferation, promote RAW264.7 cell apoptosis, decrease E-rosette formation rate and inhibit anti-tumor effects of alveolar macrophages, at the same time, these effects of gasoline engine exhaust were far stronger than those of methanol engine exhaust. In addition, gasoline engine exhaust could significantly inhibit activities of ADCC of alveolar macrophages, but methanol engine exhaust could not. These results suggested that both gasoline and methanol engine exhausts might be immunotoxic atmospheric pollutants, but some effects of gasoline engine exhaust on immunotoxicities may be far stronger than that of methanol engine exhaust. |
| | |
Authors:
|
Wangjun Che; Guiming Liu; Hong Qiu; Hao Zhang; Yun Ran; Xianggui Zeng; Weihua Wen; Ya Shu |
Related Documents
:
|
6654476 - Purification of haptoglobin and its effects on lymphocyte and alveolar macrophage respo... 10750736 - Biphasic regulation of fc-receptor mediated phagocytosis of rabbit alveolar macrophages... 15579256 - Alveolar macrophages in chronic obstructive pulmonary disease (copd). 3004226 - Crocidolite-induced pulmonary fibrosis in mice. cytokinetic and biochemical studies. 15519606 - Arsenic exposure exacerbates atherosclerotic plaque formation and increases nitrotyrosi... 11943196 - Caspase-3 is not essential for dna fragmentation in mcf-7 cells during apoptosis induce... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-20 |
Journal Detail:
|
Title: Toxicology in vitro : an international journal published in association with BIBRA Volume: 24 ISSN: 1879-3177 ISO Abbreviation: Toxicol In Vitro Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-17 Completed Date: 2010-06-17 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8712158 Medline TA: Toxicol In Vitro Country: England |
Other Details:
|
Languages: eng Pagination: 1119-25 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Kunming Center for Disease Control and Prevention, No. 4, Ziyun Road, Kunming 650228, China. chewangjun@163.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Air Pollutants
/
toxicity* Animals Apoptosis / drug effects Cell Line Cell Proliferation / drug effects Gasoline / toxicity* Macrophages, Alveolar / drug effects, immunology Methanol / toxicity* Mice Rabbits Toxicity Tests Vehicle Emissions / toxicity* |
| Chemical | |
Reg. No./Substance:
|
0/Air Pollutants; 0/Gasoline; 0/Vehicle Emissions; 67-56-1/Methanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Identification of a novel angiogenin inhibitor 1 and its association with hyaluronidase of Streptoco...
Next Document: Cyclobutane pyrimidine dimers are photosensitised by carprofen plus UVA in human HaCaT cells.