| Comparison of hesperetin and its metabolites for cholesterol-lowering and antioxidative efficacy in hypercholesterolemic hamsters. | |
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MedLine Citation:
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PMID: 20553191 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was performed to compare the hypolipidemic and antioxidant efficacy of hesperetin and its metabolites in hypercholesterolemic hamsters. The hamsters were fed a high-fat (10% coconut oil and 0.2% cholesterol, wt/wt) diet or a high-fat diet supplemented with hesperetin (0.02%) or hesperetin metabolites, 3,4-dihydroxyphenylpropionic acid (DHPP) (0.012%) and 3-methoxy-4-hydroxycinnamic acid (ferulic acid) (0.013%), for 12 weeks. Dietary DHPP and ferulic acid were found to have significantly decreased the levels of the plasma total cholesterol, non-high-density lipoprotein-cholesterol (HDL-C), apolipoprotein B, hepatic lipids, and cholesterol-regulating enzymes compared to the control group. In particular, ferulic acid was more potent with respect to raising HDL-C/total cholesterol ratio and paraoxonase levels while decreasing atherogenic index values. Hesperetin and its metabolites seemed to enhance antioxidant capacity by lowering the hydrogen peroxide and lipid peroxide (thiobarbituric acid-reactive substrates) levels. Among the hesperetin metabolites tested, the relative potency of ferulic acid for reducing the risks of atherosclerosis in hamsters was found to be greater. |
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Authors:
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Hye-Jin Kim; Seon-Min Jeon; Mi-Kyung Lee; Yun-Young Cho; Eun-Young Kwon; Jin Hee Lee; Myung-Sook Choi |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of medicinal food Volume: 13 ISSN: 1557-7600 ISO Abbreviation: J Med Food Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9812512 Medline TA: J Med Food Country: United States |
Other Details:
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Languages: eng Pagination: 808-14 Citation Subset: IM |
Affiliation:
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Foods R&D, CJ Cheiljedang Corp, Seoul, Republic of Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticholesteremic Agents / administration & dosage* Antioxidants / administration & dosage* Caffeic Acids / administration & dosage* Cholesterol / blood* Cholesterol, HDL / blood Coumaric Acids / administration & dosage* Cricetinae Disease Models, Animal Hesperidin / administration & dosage*, metabolism Humans Hypercholesterolemia / blood, drug therapy* Male Mesocricetus |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Antioxidants; 0/Caffeic Acids; 0/Cholesterol, HDL; 0/Coumaric Acids; 1078-61-1/3,4-dihydroxyphenylpropionic acid; 1135-24-6/ferulic acid; 520-26-3/Hesperidin; 520-33-2/hesperetin; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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