| Comparison of GABA-induced responses in various segments of the guinea-pig intestine. | |
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MedLine Citation:
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PMID: 3032659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In preloaded, isolated segments of duodenum, jejunum, ileum and colon, ethylenediamine (EDA) caused a 3-mercaptopropionic acid (3-MPA)-sensitive release of [3H]GABA. Both EDA and GABA caused a contraction and a delayed 'after-relaxation' in the ileum, but only a delta-aminovaleric acid (DAVA)-sensitive relaxation in other intestinal segments; these actions of EDA were reduced by 3-MPA and therefore due to release of endogenous GABA. Baclofen induced a DAVA-sensitive relaxation in all tissues. Evidently, GABA modulates cholinergic excitation of the smooth muscle at all levels of the intestine. |
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Authors:
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J Ong; D I Kerr |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 134 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1987 Feb |
Date Detail:
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Created Date: 1987-05-28 Completed Date: 1987-05-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 349-53 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ethylenediamines / pharmacology Female Guinea Pigs Intestines / drug effects Male Muscle Relaxation / drug effects Muscle, Smooth / drug effects* Receptors, GABA-A / drug effects* gamma-Aminobutyric Acid / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Ethylenediamines; 0/Receptors, GABA-A; 56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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