Document Detail


Comparison of GABA-induced responses in various segments of the guinea-pig intestine.
MedLine Citation:
PMID:  3032659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In preloaded, isolated segments of duodenum, jejunum, ileum and colon, ethylenediamine (EDA) caused a 3-mercaptopropionic acid (3-MPA)-sensitive release of [3H]GABA. Both EDA and GABA caused a contraction and a delayed 'after-relaxation' in the ileum, but only a delta-aminovaleric acid (DAVA)-sensitive relaxation in other intestinal segments; these actions of EDA were reduced by 3-MPA and therefore due to release of endogenous GABA. Baclofen induced a DAVA-sensitive relaxation in all tissues. Evidently, GABA modulates cholinergic excitation of the smooth muscle at all levels of the intestine.
Authors:
J Ong; D I Kerr
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  134     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-05-28     Completed Date:  1987-05-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  349-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Ethylenediamines / pharmacology
Female
Guinea Pigs
Intestines / drug effects
Male
Muscle Relaxation / drug effects
Muscle, Smooth / drug effects*
Receptors, GABA-A / drug effects*
gamma-Aminobutyric Acid / pharmacology*
Chemical
Reg. No./Substance:
0/Ethylenediamines; 0/Receptors, GABA-A; 56-12-2/gamma-Aminobutyric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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